Study of Fasting Lipid Profile in Patients with Subclinical Hypothyroidism in a Tertiary Care Hospital in Bangladesh

Authors

  • Mohammad Afjal Hossain Assistant Professor, Department of Endocrinology, US-Bangla Medical College, Narayanganj, Bangladesh
  • - Atiquzzaman Assistant Professor, Department of Medicine, US-Bangla Medical College, Narayanganj, Bangladesh
  • Mirza Sharifuzzaman Assistant Professor, Department of Endocrinology, Dhaka Medical College, Dhaka, Bangladesh
  • Farzana Amin Medical Officer, South East Model Hospital, Dhaka, Bangladesh
  • Lutful Kabir Assistant Professor, Department of Endocrinology, Rangpur Medical College, Rangpur, Bangladesh
  • Dahlia Sultana Assistant Professor, Department of Endocrinology, Sir Salimullah Medical College, Dhaka, Bangladesh
  • Mohammed Shafiqul Islam Bhuiyan Associate Professor, Department of Gastroenterology, US-Bangla Medical College, Narayanganj, Bangladesh

DOI:

https://doi.org/10.3329/fmcj.v16i1.55731

Keywords:

Subclinical hypothyroidism, Fasting lipid profile, Total cholesterol, Triglycerides, HDL-C, LDL-C, Thyroid stimulating hormone, Thyroxine

Abstract

Subclinical hypothyroidism (SCH) is a metabolic disorder with prevalence about 4-10% in general population. This study was conducted to observe the pattern of fasting lipid profile in SCH and to correlate the components of it with thyroid stimulating hormone and free thyroxin level. This cross sectional observational study included 31 newly diagnosed cases of SCH and 17 age and BMI matched healthy control subjects with normal thyroid function test. Fasting lipid profile was recorded and compared. TSH was significantly higher in SCH compared to controls (9.09±2.79 vs 2.31±0.92 μIU/ml; p=0.001). FT4 was comparable between the groups (1.17±0.18 vs 1.28±0.20 ng/dl; p=0.938). Significantly higher level of Total cholesterol and LDL-C were observed in SCH compared to controls (TC 194.77±29.70 vs 156.59±20.45 mg/dl; p=0.042 and LDL-C 124.81±27.85 mg/dl vs 88.59±18.41mg/dl; p=0.045 respectively). Triglycerides and HDL-C were comparable between the groups (TG 134.90±80.97 vs 118.12±49.14 mg/dl; p=0.171 and HDL-C 42.87±4.83 vs 44.47±5.66; p=0.633 respectively). TSH showed significant positive correlation with TC and LDL-C (r=0.591, p<0.001 and r=0.644, p<0.001 respectively), but not with TG or HDL-C (r=0.011, p=0.943 and r=0.115, p=0.435 respectively). FT4 only showed significant negative correlation with LDL-C (r=0.302; P=0.037) but not with TC, TG or HDL-C (TC: r=0.245, P=0.093; TG: r=0.121, p=0.411 and HDL-C: r=0.108, p=0.466 respectively). SCH is associated with raised TC and LDL-C. So patients with SCH are more vulnerable to develop future adverse cardio-metabolic complications.

Faridpur Med. Coll. J. 2021;16(1):17-20

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Published

2021-10-03

How to Cite

Hossain, M. A. ., Atiquzzaman, .-., Sharifuzzaman, M. ., Amin, F. ., Kabir, L. ., Sultana, D. ., & Islam Bhuiyan, M. S. . (2021). Study of Fasting Lipid Profile in Patients with Subclinical Hypothyroidism in a Tertiary Care Hospital in Bangladesh. Faridpur Medical College Journal, 16(1), 17–20. https://doi.org/10.3329/fmcj.v16i1.55731

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Original Articles