Correlation of Cardiac Troponin I with Left Ventricular Systolic Function in Patients with Acute ST-segment Elevated Myocardial Infarction

Authors

  • Kamal Uddin Ahmed Assistant Professor and Head, Department of Cardiology, Faridpur Medical College, Faridpur, Bangladesh
  • Mst Rabeya Bilkis Registrar, Department of Gynaecology and obstetrics, Faridpur Medical College Hospital, Faridpur, Bangladesh
  • AKM Monwarul Islam Associate Professor, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh
  • Gias Uddin Ahmed Assistant Professor, Department of Paediatrics, Faridpur Medical College, Faridpur, Bangladesh
  • Syed Md Romel Assistant Professor, Department of Cardiology, Kurmitola General Hospital, Dhaka, Bangladesh
  • Nasir Uddin Ahmed Assistant Professor, Department of Pathology, Faridpur Medical College, Faridpur, Bangladesh
  • Md Abdul Kader Akanda Professor of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/fmcj.v16i1.55735

Keywords:

Cardiac troponin I, Left ventricular ejection fraction, Myocardial infarction

Abstract

Myocardial infarction is one of the leading cause of death globally and following acute myocardial infarction prognosis depends on extent of myocardial damage. This study was aimed to correlate cardiac troponin I level with the left ventricular systolic function in patients with acute ST-elevated myocardial infarction. A total of 104 patients of acute ST-segment elevated myocardial infarction receiving streptokinase therapy within 12 hours of onset of chest pain were studied. Cardiac troponin I concentration was measured by immunometric assay and echocardiographic left ventricular ejection fraction was calculated by modified biplane Simpson's method. Left ventricular ejection fraction (LVEF) was compared with serum cardiac troponin I concentration. Study subjects were divided into two groups on the basis of LVEF. In group I, there were 54 patients with LVEF < 50% and in group II, there were 50 patients with LVEF >_ 50%. The mean cTnI within 12 hours of onset was 129 ± 8.7 ng/ml in group I and11 ± 2.1 ng/ml group II and the difference was statistically significant (p<0.001). Serum cardiac troponin I concentration has a strong negative correlation with left ventricular ejection fraction after first acute myocardial infarction. A level of serum cardiac troponin I >_ 6.6 ng/ml provided a good indication for LVEF <50% and this can be used to detect patients with higher risk.

Faridpur Med. Coll. J. 2021;16(1):34-38

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Author Biographies

Gias Uddin Ahmed, Assistant Professor, Department of Paediatrics, Faridpur Medical College, Faridpur, Bangladesh

Myocardial infarction is one of the leading cause of death globally and following acute myocardial infarction prognosis depends on extent of myocardial damage. This study was aimed to correlate cardiac troponin I level with the left ventricular systolic function in patients with acute ST-elevated myocardial infarction. A total of 104 patients of acute ST-segment elevated myocardial infarction receiving streptokinase therapy within 12 hours of onset of chest pain were studied. Cardiac troponin I concentration was measured by immunometric assay and echocardiographic left ventricular ejection fraction was calculated by modified biplane Simpson's method. Left ventricular ejection fraction (LVEF) was compared with serum cardiac troponin I concentration. Study subjects were divided into two groups on the basis of LVEF. In group I, there were 54 patients with LVEF < 50% and in group II, there were 50 patients with LVEF >_ 50%. The mean cTnI within 12 hours of onset was 129 ± 8.7 ng/ml in group I and11 ± 2.1 ng/ml group II and the difference was statistically significant (p<0.001). Serum cardiac troponin I concentration has a strong negative correlation with left ventricular ejection fraction after first acute myocardial infarction. A level of serum cardiac troponin I >_ 6.6 ng/ml provided a good indication for LVEF <50% and this can be used to detect patients with higher risk.Faridpur Med. Coll. J. 2021;16(1):34-38

Syed Md Romel, Assistant Professor, Department of Cardiology, Kurmitola General Hospital, Dhaka, Bangladesh

Myocardial infarction is one of the leading cause of death globally and following acute myocardial infarction prognosis depends on extent of myocardial damage. This study was aimed to correlate cardiac troponin I level with the left ventricular systolic function in patients with acute ST-elevated myocardial infarction. A total of 104 patients of acute ST-segment elevated myocardial infarction receiving streptokinase therapy within 12 hours of onset of chest pain were studied. Cardiac troponin I concentration was measured by immunometric assay and echocardiographic left ventricular ejection fraction was calculated by modified biplane Simpson's method. Left ventricular ejection fraction (LVEF) was compared with serum cardiac troponin I concentration. Study subjects were divided into two groups on the basis of LVEF. In group I, there were 54 patients with LVEF < 50% and in group II, there were 50 patients with LVEF >_ 50%. The mean cTnI within 12 hours of onset was 129 ± 8.7 ng/ml in group I and11 ± 2.1 ng/ml group II and the difference was statistically significant (p<0.001). Serum cardiac troponin I concentration has a strong negative correlation with left ventricular ejection fraction after first acute myocardial infarction. A level of serum cardiac troponin I >_ 6.6 ng/ml provided a good indication for LVEF <50% and this can be used to detect patients with higher risk.Faridpur Med. Coll. J. 2021;16(1):34-38

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Published

2021-10-03

How to Cite

Ahmed, K. U. ., Bilkis, M. R. ., Islam, A. M. ., Ahmed, G. U. ., Md Romel, S. ., Ahmed, N. U. ., & Akanda, M. A. K. . (2021). Correlation of Cardiac Troponin I with Left Ventricular Systolic Function in Patients with Acute ST-segment Elevated Myocardial Infarction. Faridpur Medical College Journal, 16(1), 34–38. https://doi.org/10.3329/fmcj.v16i1.55735

Issue

Vol. 16 No. 1 (2021)

Section

Original Articles