In vitro Study on Interaction of Ketotifen Fumerate with Paracetamol

Authors

  • Mohammed Aktar Sayeed Assistant Professor, Department of Pharmacy, International Islamic University Chittagong
  • Sohel Rana Professor, Department of Pharmacy, Jahangirnagar University.

DOI:

https://doi.org/10.3329/iiucs.v7i0.12258

Keywords:

Stability constant, Job’s method, Ardon’s mehod, ketotifen, paracetamol

Abstract

Interaction of ketotifen fumerate and paracetamol was studied in aqueous media. The ability of interaction of ketotifen with paracetamol is dependent on pH of the solution and it has been found that ketotifen forms 1:1 complexes at different pH. The stability constants have been calculated from the Ardons spectrophotomeric measurements of the reaction systems. When ketotifen was interacted with paracetamol and the absorbance was determined at 300 nm the stability constants were found of - 7.32 and -7.84 at pH 1.6 and 7.4 respectively.

DOI: http://dx.doi.org/10.3329/iiucs.v7i0.12258

IIUC Studies Vol.7 2011: 49-54

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Published

2012-10-19

How to Cite

Sayeed, M. A., & Rana, S. (2012). In vitro Study on Interaction of Ketotifen Fumerate with Paracetamol. IIUC Studies, 7, 49–54. https://doi.org/10.3329/iiucs.v7i0.12258

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Section

Articles - English Section