Phytochemical and biological investigation on Artocarpus chaplasha Roxb

Authors

  • Sanjida Sharmin Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka, Dhaka
  • Fakir Shahidullah Tareq Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka, Dhaka
  • Choudhury Mahmood Hasan Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka, Dhaka
  • Monira Ahsan Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/iiucs.v14i1.37654

Keywords:

Artocarpus chaplasha, chemical constituents, antioxidant, antimicrobial, cytotoxicity

Abstract

The methanolic extract of the stem bark of Artocarpus chaplasha Roxb. (Family: Moraceae) was investigated for the isolation of pure compounds and determination of few biological activities. A mixture of two compounds cycloartenyl acetate and lupeol acetate were isolated from it. The crude methanol extract as well as its petroleum ether, chloroform, carbon tetrachloride and aqueous soluble fractions were studied for antioxidant, cytotoxic and antimicrobial activities. Among the different fractions, the aqueous soluble partitionate was found to have most potent antioxidant activity as compared to tertbutyl-1- hydroxytoluene. Antimicrobial screening of the different fractions was performed using the disc diffusion method. In these tests, the chloroform soluble fraction and carbon tetrachloride soluble fraction of methanolic extract exhibited moderate antimicrobial activity (range of zone of inhibition 8-12 mm). In brine shrimp lethality test, the petroleum ether soluble extract exhibited the highest level of cytotoxicity.

IIUC Studies Vol.14(1) June 2017: 45-52

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Author Biography

Sanjida Sharmin, Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka, Dhaka



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Published

2018-07-29

How to Cite

Sharmin, S., Tareq, F. S., Hasan, C. M., & Ahsan, M. (2018). Phytochemical and biological investigation on Artocarpus chaplasha Roxb. IIUC Studies, 14(1), 45–50. https://doi.org/10.3329/iiucs.v14i1.37654

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Section

Articles