Vitamin D, intact parathyroid hormone, and bone mineral density in postmenopausal women

Authors

  • Farhana Afrooz Assistant Professor, Department of Endocrinology and Metabolism, Dr. Sirajul Islam Medical College, Dhaka
  • Mohammad Shamsul Alam Assistant professor, Department of Orthopedic Surgery, Dhaka Medical College, Dhaka
  • Mahbuba Shabnam Assistant Professor, Department of Medicine, Green Life Medical College, Dhaka
  • Rumana Tasnim Assistant Professor, Department of Pharmacology and Therapeutics, Green Life Medical College, Dhaka
  • Md Mohi Uddin Junior Consultant, Department of Medicine, Dhaka Medical College Hospital, Dhaka
  • Farhana Wahab Junior Consultant, Department of Dermatology, Govt. Employee Hospital, Dhaka
  • Naznin Fatema Assistant Professor, Department of Medicine, Chattogram Ma o Shishu Medical College, Chattogram
  • Indrajit Prasad Professor, Department of Endocrinology and Metabolism, Dhaka Medical College, Dhaka

DOI:

https://doi.org/10.3329/jacedb.v3i2.78641

Keywords:

Osteoporosis, Vitamin D, Parathyroid hormone, Postmenopausal women

Abstract

Background: Osteoporosis and vitamin D deficiency (VDD) are growing concerns for the elderly population, especially postmenopausal women worldwide. The association between osteoporosis and VDD among Bangladeshi postmenopausal women was not adequately evaluated.

Objective: To assess the association between VDD, intact parathyroid hormone (iPTH) status, and bone mineral density (BMD) status among postmenopausal Bangladeshi women.

Methods: This single-center, cross-sectional study included 60 postmenopausal women. A pre-designed case record form was used to record baseline demographic variables. BMD was assessed using dual-energy X-ray absorptiometry on eligible patients who met the inclusion and exclusion criteria, where T-scores indicating normal (> -1), osteopenia (-1 to -2.5), or osteoporosis (< -2.5) based on lumbar spine (LS) and femoral neck (FN) measurements. Vitamin D was categorized as deficient (<20 ng/mL), insufficient (VDI: 20–29 ng/mL), or sufficient (≥30 ng/mL) based on serum 25(OH)D levels. Vitamin D and iPTH were measured by chemiluminescence immunoassay.

Results: Among 60 postmenopausal women, 43.3% had osteoporosis and 56.7% had no osteoporosis. VDD, insufficiency, and sufficiency were present in 50%, 35%, and 15% respectively in the study participants. Serum iPTH was higher in 20.0% of the study participants. Vitamin D levels were lower in women with osteoporosis than those without [15.6±5.5 vs. 20.6±8.9, p <0.001]. Serum iPTH negatively and moderately correlated with 25(OH)D and LS-BMD [both: r=-0.4, p=0.001] but not with FN-BMD. In multivariate regression analysis, only serum iPTH [B=0.4, p=0.001] and vitamin D insufficiency [B= 0.5, p=0.015] had a predictive association with LS-BMD.

Conclusion: Both VDD and osteoporosis, are common in postmenopausal Bangladeshi women. Low vitamin D levels can play a role in developing osteoporosis by increasing bone remodeling as an effect of raised iPTH.

J Assoc Clin Endocrinol Diabetol Bangladesh, July 2024;3(2): 47-52

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Published

2024-12-30

How to Cite

Afrooz, F., Alam, M. S., Shabnam, M., Tasnim, R., Uddin, M. M., Wahab, F., … Prasad, I. (2024). Vitamin D, intact parathyroid hormone, and bone mineral density in postmenopausal women. Journal of Association of Clinical Endocrinologist and Diabetologist of Bangladesh, 3(2), 47–52. https://doi.org/10.3329/jacedb.v3i2.78641

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Original Article