Comparison of efficacy and safety between Tacrolimus and Hydrocortisone acetate in 2-5 years old children with atopic dermatitis

Authors

  • Quazi Salim Yazdi Assistant Professor of Dermatology, AFMC, Dhaka
  • Md Shamsul Huda Former Adviser Specialist of Dermatology, AFMC, Dhaka
  • Abdul Latif Khan Classified Specialist of Dermatology, CMH, Dhaka
  • Md Sayeed Hasan Associate Professor of Dermatology, AFMC, Dhaka
  • Mushtaq Ahmad Associate Professor & Head of the Dept of Forensic Medicine & Toxicology, AFMC, Dhaka
  • Tawhida Nawazesh Rosie Graded Specialist of Dermatology, CMH, Dhaka

DOI:

https://doi.org/10.3329/jafmc.v10i1.22924

Keywords:

atopic dermatitis, tacrolimus, hydrocortisone acetate

Abstract

Introduction: Atopic dermatitis is a recurrent inflammatory skin disease with intense pruritus as its hallmark symptom. It often follows a chronic, relapsing course.

Objectives: This comparative study was done with an aim to find out the efficacy of Tacrolimus and Hydrocortisone acetate in 2-5 year old children with Atopic dermatitis.

Methods: This clinical trial was carried out on two equal groups of 60 patients. Group A was treated with topical tacrolimus ointment (0.03%) and group B with hydrocortisone acetate ointment (1%). Follow up was done at week 1, 2, 4, 8 and 12 of treatment for assessment of improvement and adverse event, which was measured by overall clinical improvement in the physician's global evaluation of clinical response. Data was collected in a predesigned data collection sheet, and analysis was performed by SPSS program (Version 12).

Results: Excellent, marked and moderate improvement were observed in 19 (63.3%), 9 (30.0%), and 2(6.7%) patients of tacrolimus group and 1(3.3%), 2(6.7%) and 27(90.0%) patients of hydrocortisone group respectively. Tacrolimus group had significantly better improvement than hydrocortisone group (p<0.001). Skins burning at application site were observed significantly more in tacrolimus group 8(26.7%) than in hydrocortisone group 2 (6.7%). 53 JAFMC Bangladesh. Vol 10, No 1 (June) 2014

Conclusion: The study showed tacrolimus ointment is more effective than hydrocortisone acetate in the treatment of atopic dermatitis in paediatric patients.

DOI: http://dx.doi.org/10.3329/jafmc.v10i1.22924

Journal of Armed Forces Medical College Bangladesh Vol.10(1) 2014

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Author Biography

Quazi Salim Yazdi, Assistant Professor of Dermatology, AFMC, Dhaka



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Published

2015-04-07

How to Cite

Yazdi, Q. S., Huda, M. S., Khan, A. L., Hasan, M. S., Ahmad, M., & Rosie, T. N. (2015). Comparison of efficacy and safety between Tacrolimus and Hydrocortisone acetate in 2-5 years old children with atopic dermatitis. Journal of Armed Forces Medical College, Bangladesh, 10(1), 53–58. https://doi.org/10.3329/jafmc.v10i1.22924

Issue

Vol. 10 No. 1 (2014)

Section

Original Papers

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.