Evaluation of Pleural Fluid Adenosine Deaminase Activity in Tubercular Pleural Effusion in a Military Hospital

Authors

  • Md Kabir Uddin Assistant Professor of Medicine and Respiratory Medicine, CMH Dhaka
  • Md Abdul Ali Mia Consultant Physician General, Bangladesh Armed Forces, Dhaka
  • Mamun Mostafi Chief Physician, CMH Dhaka
  • Mimi Parvin Classified Spl in Pathology, AFIP, Dhaka
  • Mainul Ahmed Chowdhury MD(Med), Classified Spl in Medicine, CMH Dhaka

DOI:

https://doi.org/10.3329/jafmc.v11i2.39826

Keywords:

Adenine deaminase (ADA), Tubercular pleural effusion (TPE), Malignant pleural effusion (MPE).

Abstract

Introduction: Tubercular pleural effusion (TPE) is one of the common extra pulmonary tuberculosis which many a times become difficult to make definite diagnosis on account of low sensitivity and/or specificity of non-invasive diagnostic tools. Even pleural biopsy cannot establish all the diagnosis; rather after patient shows unwillingness to invasive procedure. A reliable sensitive and specific marker is required for early diagnosis of TPE as Bangladesh is a high Tuberculosis burden country. Adenine deaminase (ADA) may be a useful surrogate marker.

Objective: To find out a reliable sensitive and specific marker for early diagnosis of TPE as Bangladesh is a high Tuberculosis burden country.

Materials and Methods: This study carried out ADA estimations in 170 cases of pleural effusion at Combined Military Hospital (CMH) Dhaka. Efforts were made to reach diagnosis by other means.

Results: ADA level was found in tubercular pleural effusion ranges from 25 to 180 with a mean 71.51 ±33.1. It ranges 3 U/L to 170U/L with non-tubercular effusion with a mean 20.96±16.71. The sensitivity of ADA is 90.9% and specificity is 95.7% in diagnosing TPE. The positive and negative predictive values are 90.91 % and 95.65% respectively.

Conclusion: ADA is found cheap, sensitive and a useful surrogate marker. However, it is not a confirmatory diagnostic tool but can be used as a reliable adjunct to other investigations.

Journal of Armed Forces Medical College Bangladesh Vol.11(2) 2015: 69-75

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Author Biography

Md Kabir Uddin, Assistant Professor of Medicine and Respiratory Medicine, CMH Dhaka

Dept. of Medicine and Respiratory Medicine

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Published

2019-01-16

How to Cite

Uddin, M. K., Mia, M. A. A., Mostafi, M., Parvin, M., & Chowdhury, M. A. (2019). Evaluation of Pleural Fluid Adenosine Deaminase Activity in Tubercular Pleural Effusion in a Military Hospital. Journal of Armed Forces Medical College, Bangladesh, 11(2), 69–75. https://doi.org/10.3329/jafmc.v11i2.39826

Issue

Vol. 11 No. 2 (2015)

Section

Original Papers

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.