Oxidative Stress and Antioxidant Status in Schizophrenia Patients

Authors

  • Fatema Zerin Khan Instructor of Pharmacology, AFMI, Dhaka
  • Syeda Papia Sultana Assistant Professor of Pharmacology, Ashiyan Medical College, Dhaka
  • Mohammad SI Mullick Professor and Former Chairman, Department of Psychiatry, BSMMU, Dhaka
  • Nargis Akhter Formar Professor, Department of Pharmacology, BSMMU, Dhaka.

DOI:

https://doi.org/10.3329/jafmc.v12i2.41087

Keywords:

Schizophrenia, Malondialdehyde, Glutathione, α-Tocopherol, Ascorbic acid, Oxidative stress.

Abstract

Introduction: Oxidative stress has been assumed to contribute to the pathophysiology of schizophrenia. Increased oxidative stress is the result of either an increased production of free radicals or a depletion of the endogenous antioxidants.

Objective: To assess the levels of oxidative stress and antioxidant status in schizophrenia.

Materials and Methods: This observational study was carried out in the department of Pharmacology, Bangabandhu Sheikh Mujib Medical University from September 2013 to January 2015. Ninety three schizophrenia patients were enrolled as study group and 30 healthy indivuduals were taken as control group. The peripheral levels of several molecules associated with oxidative stress namely malondialdehyde (MDA), glutathione (GSH) and anti-oxidant status like plasma levels of ascorbic acid (vitamin C) and α-tocopherol (vitamin E) in 93 patients with schizophrenia and 30 healthy participants were assessed.

Results: Study found that the schizophrenia group presented substantially higher levels of oxidative stress than the control group, as revealed by elevated quantities of the pro-oxidant MDA (6.3±0.5μmol/L in study group and 2.1±0.5μmol/L in control group), decreased levels of the antioxidants GSH (0.6±0.2mg/gm of Hb in study group and 2.1±0.5mg/gm of Hb in control group), plasma α-tocopherol and ascorbic acid. Results found were highly significant (p=0.001).

Conclusion: In schizophrenia there are increased level of oxidative stress and decreased level of the antioxidants.

Journal of Armed Forces Medical College Bangladesh Vol.12(2) 2016: 40-43

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Published

2016-12-01

How to Cite

Khan, F. Z., Sultana, S. P., Mullick, M. S., & Akhter, N. (2016). Oxidative Stress and Antioxidant Status in Schizophrenia Patients. Journal of Armed Forces Medical College, Bangladesh, 12(2), 40–43. https://doi.org/10.3329/jafmc.v12i2.41087

Issue

Vol. 12 No. 2 (2016)

Section

Original Papers

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.