Outcome of Oligonodular Hepatocellular Carcinoma after Hepatectomy

Authors

  • SM Shakhwat Hossain Diploma in Hepatobiliary Surgery (China), Advanced Training in HBPS (Singapore), Classified Specialist in Surgery & Head of the Department of Hepatobiliary Surgery, CMH, Dhaka, Bangladesh
  • Md Mahboob Hasan Diploma in Hepatobiliary Surgery (China), Classified Specialist in Surgery and Hepatobiliary Surgeon, CMH, Dhaka, Bangladesh
  • Md Mahbubur Rahman Fellow Colorectal Surgery (France), Consultant Surgeon General, Directorate General of Medical Services, Ministry of Defence, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jafmc.v15i1.48643

Keywords:

Hepatocellular carcinoma, Oligonodular, Intrahepatic metastasis and Recurrence

Abstract

Introduction: Hepatocellular carcinoma (HCC) is a common cancer and is the third most common cause of cancer-related death worldwide. Frequent recurrence of HCC after resection is a major surgical limitation. Early recurrence is the most disappointing outcome after surgery for multinodular HCC. Several studies found good results after hepatectomy for oligonodular (2 or 3 nodules) HCC.

Objectives: To observe the recurrence rate three months after hepatectomy for oligonodular HCC and study the possible risk factors.

Materials and Methods: The study population consisted of 102 patients with oligonodular HCC and received hepatectomy in Combined Military Hospital (CMH) between July 2011 and July 2017 according to the following criteria: (1) numbers of tumour nodules determined by preoperative imaging (computed tomography or magnetic resonance imaging) and intraoperative exploration; (2) diagnosis of HCC confirmed by postoperative histopathology; (3) incision margins negative; (4) complete clinicopathologic data; (5) adjuvant chemotherapy advised one month after operation. Multicentric occurrence (MO) and intrahepatic metastasis (IM) were determined in each patient according to the histopathologic examination.

Results: Among 102 patients, 43(42.2%) had small tumor stain three months after surgery, 22(21.6%) and 21(20.6%) were definded as single and multiple recurrence respectively. The recurrence rate of patients with microvascular involvement was higher (64.3%) than those without (33.8%), (p<0.05). IM or MO, complete tumor capsule or not, number of tumors (2 versus 3), liver condition (cirrhosis versus chronic hepatitis) showed no significant difference.

Conclusion: There was a high rate of very early recurrence for patients with oligonodular HCC three months ater hepatectomy, and the hepatic resection seems no-account for these patients regardless of very early recurrence or not a curative resection. Microvascular involvement was a risk factor while IM or MO is not.

Journal of Armed Forces Medical College Bangladesh Vol.15 (1) 2019: 55-57

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Published

2020-08-20

How to Cite

Hossain, S. S., Hasan, M. M., & Rahman, M. M. (2020). Outcome of Oligonodular Hepatocellular Carcinoma after Hepatectomy. Journal of Armed Forces Medical College, Bangladesh, 15(1), 55–57. https://doi.org/10.3329/jafmc.v15i1.48643

Issue

Vol. 15 No. 1 (2019)

Section

Original Papers

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.