Down Syndrome and Van Wyk-Grumbach Syndrome: A Rare Presentation

Authors

  • Eva Jesmin Classified Child Specialist and Paediatric Endocrinologist, Combined Military Hospital (CMH), Dhaka, Bangladesh
  • Fauzia Mohsin Head of Paediatrics Endocrinology Unit, Department of Paediatrics, BIRDEM General Hospital-II, Bangladesh

DOI:

https://doi.org/10.3329/jafmc.v18i1.61270

Keywords:

Down Syndrome, VWGS

Abstract

Van Wyk-Grumbach Syndrome (VWGS) is presented by juvenile hypothyroidism, delayed bone age and isosexual precocious puberty. All of the features will be reversed with treatment of the underlying thyroid hormone deficiency. It has been described, a 3- year-old girl with Down Syndrome who presented with per vaginal bleeding. Physical examination showed typical morphologic features of Down Syndrome and hypothyroidism. Pubertal developments in tanner stages were: breast at stage II and pubic hair at stage I. Serum TSH level was very high. Serum FSH, LH and Estrogen level were also high for her age. On radiological examination her bone age was 2 years. Her pelvic sonogram revealed enlarged uterus with ovarian cysts. These findings confirmed the diagnosis of VWGS. Treatment with Levothyroxine, her vaginal bleeding did not recur and ovarian cyst size decreased after 4 weeks and disappeared after 2 months. In conclusion, thyroid hypo-function must be investigated in children who have precocious puberty with multicystic enlarged ovaries.

JAFMC Bangladesh. Vol 18, No 1 (June) 2022: 97-99

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Published

2022-10-16

How to Cite

Jesmin, E. ., & Mohsin, F. . (2022). Down Syndrome and Van Wyk-Grumbach Syndrome: A Rare Presentation. Journal of Armed Forces Medical College, Bangladesh, 18(1), 97–99. https://doi.org/10.3329/jafmc.v18i1.61270

Issue

Vol. 18 No. 1 (2022)

Section

Case Reports

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.