A Retrospective Study on Previously Untreated Non-metastatic Breast Cancer Patients at a Tertiary Care Hospital

Authors

  • Md Quadrat E Elahi Advisor Specialist in Medicine & Head of the Department of Medical Oncology, Cancer Centre, CMH, Dhaka
  • Md Azizul Islam Consultant Physician General, Bangladesh Armed Forces, Ministry of Defence, Dhaka
  • SM Rahid Sarwar Professor of Medicine, AFMC, Dhaka
  • Fatima Sarkar Classified Specialist in Medicine & Medical Oncology, Cancer Center, CMH, Dhaka

DOI:

https://doi.org/10.3329/jafmc.v18i2.63987

Keywords:

Progression free survival, Breast cancer, Overall survival, AC, EC, Taxanes, Combined Military Hospital (CMH)

Abstract

Introduction: The combination of adoxorubicin and cyclophosphamide (AC) followed by a taxane (Docetaxel or Paclitaxel) and epirubicin and cyclophosphamide (EC) followed by a taxane (Docetaxel or Paclitaxel) is a standard regimen for breast cancer patients. In this study, we compared the three-year overall survival (OS) and progression free survival (PFS) of a patient with previously untreated non-metastatic breast cancer patients.  

Objectives: To find out the overall survival and progression free survival among previously untreated non-metastatic breast cancer patients after standard chemotherapy. 

Methods: Fifty-six patients received four cycles of doxorubicin at a dose of 60mg/m2 and cyclophosphamide at a dose of 600 mg/m2 followed by four cycles of paclitaxel at a dose of 175mg/m2. Thirteen patients received AC followed by four cycles of docetaxel at a dose of 75mg/m2. Twenty-one patients received four cycles of epirubicin (75mg/m2) and cyclophosphamide (600mg/m2), followed by four cycles of paclitaxel (175mg/m2). Twelve patients were given EC followed by four cycles of docetaxel (75mg/m2).

Results: The four groups of patients had similar characteristics. Overall survivalafter three years was 92% in AC followed by paclitaxel, 98% in AC followed by docetaxel, 95% and 97% in EC followed by paclitaxel and docetaxel respectively. One year of PFS in AC followed by paclitaxel and docetaxel was 98% and 100% respectively whereas in EC followed by paclitaxel and docetaxel were 98% and 98% respectively. The four arms had 96%, 98%, 97% and 96% PFS after two years respectively. This research also revealed that four chemotherapy regimens had three-year survival rates of 93%, 98%, 93% and 96% respectively.

Conclusion: AC or EC followed by taxane regimens well suitable regimens for the population of patients with previously untreated non-metastatic breast cancer patients. The findings show the need for continued observation as well as taking into account the treatment of other patients throughout different periods.

JAFMC Bangladesh. Vol 18, No 2 (December) 2022: 11-14

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Published

2023-08-21

How to Cite

Elahi, M. Q. E. ., Islam, M. A. ., Sarwar, S. R. ., & Sarkar, F. . (2023). A Retrospective Study on Previously Untreated Non-metastatic Breast Cancer Patients at a Tertiary Care Hospital. Journal of Armed Forces Medical College, Bangladesh, 18(2), 11–14. https://doi.org/10.3329/jafmc.v18i2.63987

Issue

Vol. 18 No. 2 (2022)

Section

Original Papers

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.