Clinical Characteristics and Risk Factors Analysis of COVID-19 Infections- A Single Center Observational Study

Authors

  • Mohammad Abdul Quddus Bhuiyan Professor of Medicine, Armed Forces Medical College, Dhaka
  • Md Zukfikkar Alam Trainee Officer in MMEd Course, Armed Forces Medical Institute, Dhaka
  • Md Nurun Nabi Classified Specialist in Pathology, Combined Military Hospital, Sylhet
  • Umar Rashed Munir Assistant Director of Medical Services, 17 Infantry Division, Sylhet

DOI:

https://doi.org/10.3329/jafmc.v18i2.63989

Keywords:

Coronavirus Disease 2019 (COVID-19), Acute Respiratory Distress Syndrome (ARDS), Reverse- Transcriptase-Polymerase Chain Reaction (RT-PCR)

Abstract

Introduction: COVID-19 emerged as a major public health outbreak in late 2019. Bangladesh reported its first case on 8th March 2020 and at Sylhet Div area, first case detected in April 2020, authority adopted a policy of extensive contact tracing, quarantine and initially hospitalizing of all cases. Clinical characteristics of COVID-19 cases have been described as per national and WHO guideline.

Objectives: To analyze clinical characteristics and the risk factors of COVID-19 infection.

Methods: Clinical records of all COVID-19 confirmed cases aged ≥12 years admitted to COVID Unit or treated at home isolation with complete outcomes at Sylhet area were included in the study. Duration of this study was 1st April to 27th December 2020. Epidemiological history, comorbidities, clinical features, investigations, management and complications of all cases were recorded in preform data sheet and analyzed. Variables were compared between mild and severe diseases.

Results: The sample comprised of 515 cases (mean age 30.98 years, male 81.55%). Majority were mild (92%) and 6.4% required intensive care, with 85% admitted within the first five days. Older age (≥51 years), underlying comorbidities, cough, breathlessness, reduced oxygen saturation and abnormal chest radiographs on admission were significant determinants for severity. The case fatality rate was 0.77% and the four commonest complications were ARDS (4.40%). liver injuries (4.07%), bacteraemia (2.33%) and kidney injuries (1.16%).

Conclusion: Lower case fatality rate was possibly contributed by young cases with mild diseases and early hospitalization. Abnormal chest radiographic, elderly and other comrbidities require frequent measurement of oxygen saturation with pulse oximetry and close monitoring within the first few days to detect early deterioration and to take appropriate measures. Ivermectin seems to be effective in the treatment of Covid-19 infection but need further large multi-center case control study.

JAFMC Bangladesh. Vol 18, No 2 (December) 2022: 19-23

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Published

2023-08-21

How to Cite

Bhuiyan, M. A. Q. ., Alam, M. Z. ., Nabi, M. N. ., & Munir, U. R. . (2023). Clinical Characteristics and Risk Factors Analysis of COVID-19 Infections- A Single Center Observational Study. Journal of Armed Forces Medical College, Bangladesh, 18(2), 19–23. https://doi.org/10.3329/jafmc.v18i2.63989

Issue

Vol. 18 No. 2 (2022)

Section

Original Papers

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.