Evaluation of Humoral Immune Response in COVID-19 Patients- A Comparative Study

Authors

  • Suraiya Akhtar Brig Gen Suraiya Akhtar, MBBS, DCP, MCPS, FCPS, Principal, Army Medical College, Cumilla
  • Susane Giti Maj Gen Susane Giti (retd), MBBS, MCPS, FCSP, MMEd, Ex-Commandant, AFIP, Dhaka
  • Arif Ahmed Khan Brig Gen Arif Ahmed Khan, MBBS, FCPS, MCPS, Deputy Commandant, AFIP, Dhaka
  • Md Mazharul Islam Khan Col Md Mazharul Islam Khan, MBBS, MPH, Commanding Officer, CMH, Savar
  • Md Suhil Ibne Azam Capt Md Suhil Ibne Azam, MBBS, Medical Officer, CMH Savar

DOI:

https://doi.org/10.3329/jafmc.v19i2.72450

Keywords:

SARS-CoV-2 virus, IgG, IgM seropositivity.

Abstract

Background: The novel coronavirus SARS-CoV-2 is a newly emerging virus. Positive detection of SARS-CoV-2 RNA by RT-PCR has been used to confirm SARS-CoV-2 infection. Recently positive detection of IgG and IgM antibodies specific to SARS-CoV-2 has also been recognized as deterministic evidence for confirmed SARS-CoV-2 infection. The antibody response in COVID-19 patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated.

Objective: To better clarify the humoral immune response during SARS-CoV-2 infection.

Methods: This cross sectional study was carried out on 200 RT-PCR confirmed COVID-19 cases. For better evaluation of antibody response, patients were divided into two groups, group I and group II, each consisting of 100 persons.

Results: Out of a total 200 cases antibody was detected in 104(52%) cases and antibody not detected in 96(48%) cases. Out of 104 seropositive cases only IgG was detected in 69.2% cases, only IgM in 10.6% cases and both IgG, IgM in 20.2% cases.In group I seropositivity was 68%. IgG, IgM and both IgG, IgM positivity were 58.8%, 14.7% and 26.5% respectively. In group II seropositivity was 36 %. Positivity for IgG, IgM and both IgG, IgM were 88.9%, 2.8% and 8.3% respectively.

Conclusion: As we learn more about the long-term implications of COVID-19 on recovered individuals, antibody tests can be used to increase this understanding of the immune system response to SARS-CoV-2, quantify the magnitude of the COVID-19 outbreak and effectively manage patients.

JAFMC Bangladesh, Vol 19, No 2 (December) 2023: 3-6

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Published

2024-06-10

How to Cite

Akhtar, S. ., Giti, S. ., Khan, A. A. ., Khan, M. M. I. ., & Azam, M. S. I. . (2024). Evaluation of Humoral Immune Response in COVID-19 Patients- A Comparative Study. Journal of Armed Forces Medical College, Bangladesh, 19(2), 03–06. https://doi.org/10.3329/jafmc.v19i2.72450

Issue

Vol. 19 No. 2 (2023)

Section

Original Papers

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.