TY - JOUR AU - Iqbal, Mohammad Faruq AU - Chowdhury, Arif Imtiyaz AU - Rushdi Aziz, Sharkar PY - 2022/02/22 Y2 - 2024/03/28 TI - Role of C-reactive Protein, Leucocyte and Neutrophil Count in Diagnosis of Acute Appendicitis JF - Journal of Armed Forces Medical College, Bangladesh JA - J. Armed Forces Med. Coll. VL - 17 IS - 1 SE - Original Papers DO - 10.3329/jafmc.v17i1.56717 UR - https://banglajol.info/index.php/JAFMC/article/view/56717 SP - 26-29 AB - <p><strong>Introduction: </strong>Acute appendicitis is the most common cause of surgical acute abdomen and appendicectomy is the most commonly done surgery. Accurate preoperative diagnosis can reduce negative appendicectomy rate.</p><p><strong>Objective: </strong>To evaluate the diagnostic accuracy of C-reactive protein (CRP), total leucocyte count (TLC) and neutrophil count in patients operated after clinical diagnosis of acute appendicitis.</p><p><strong>Materials and Methods: </strong>This cross-sectional observational study was conducted among 100 patients at Combined Military Hospital, Dhaka from August 2012 to January 2013. Serum CRP level was measured by latex agglutination method which is a qualitative test and level of 6 mg / L was considered positive. TLC and neutrophil count were estimated by processing blood sample through automated haematology analyzer. TLC level of 10.5 x 109/L and differential count of neutrophil more than 75% were considered elevated.</p><p><strong>Results: </strong>Out of 100 cases the mean age of the patients was 21.7 years and 65 patients were male and 35 patients were female with male to female ratio 1.85:1. Majority cases (54%) were in the age group of 11-20 years. Clinical diagnosis was correct in 93% cases and negative appendicectomy rate was 07% (p&lt;0.001). Appendix was found mostly inflamed (83%) and gangrenous (10%). CRP was highly sensitive (84.9%) and specific (85.7%) with diagnostic accuracy of 85%. TLC was also found equally sensitive and specific with diagnostic accuracy of 83%. Overall diagnostic accuracy of neutrophil was 76%.</p><p><strong>Conclusion: </strong>Diagnosis of acute appendicitis is essentially clinical supported by simple laboratory investigations like TLC and neutrophill count. Elevated levels of CRP, TLC and neutrophill count are helpful in confirming a suspected diagnosis of acute appendicitis. Appendicitis is very unlikely if the CRP, TLC and neutrophill counts are normal.</p><p>JAFMC Bangladesh. Vol 17, No 1 (June) 2021: 26-29</p> ER -