@article{Lim_Oh_Jeong_Song_Koo_Seo_2019, title={Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs}, volume={6}, url={https://banglajol.info/index.php/JAVAR/article/view/44123}, abstractNote={<p><strong>Objective: </strong>We performed a randomized two-way crossover study to evaluate the pharmacokinetic profiles of two high-dose ascorbic acid (AA) after IV infusion in healthy beagle dogs.</p> <p><strong>Materials and Methods: </strong>The dogs were administered IV AA at two doses of 1.5 and 3 gm/kg for 4 h, and the AA concentration in plasma and urine pH was measured before and after administration.</p> <p><strong>Results: </strong>The plasma concentrations of AA in both groups peaked 3 h after administration. Among the two groups, the urine pH was not significantly different (<em>p </em>= 0.1299–0.7944). High-dose IV AA did not induce serious adverse events in dogs.  </p> <p><strong>Conclusion: </strong>The results of this study suggest that the high dose of AA which reaches the therapeutic dose for cancer and supports the safety of high-dose IV AA in dogs.</p> <p>J. Adv. Vet. Anim. Res., 6(4): 481-485, December 2019</p>}, number={4}, journal={Journal of Advanced Veterinary and Animal Research}, author={Lim, Seula and Oh, Ye In and Jeong, Jong Woo and Song, Kun Ho and Koo, Tae Sung and Seo, Kyoung Won}, year={2019}, month={Nov.}, pages={481–485} }