Synthesis of Schiff Base having a Heterocyclic Moiety along with its Cyclized Derivatives and Study of their Antifungal Activities

Authors

  • Rabeya Khatun Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342
  • AS Mansarul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342
  • MA Hai Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342

DOI:

https://doi.org/10.3329/jbcs.v25i1.11765

Keywords:

Cyclized, Derivatives

Abstract

Syntheses of Schiffs base1 1-[(2, 4-difluorophenyl)-2-(1H-1, 2, 4-triazol-1-yl)] ethanone thiosemicarbazone (1A) prepared by condensation of 1-(2,4- difluorophenyl)-2-[1(H)-1,2,4-triazol-1-yl] ethanone with thiosemicarbazide, followed by cyclization2 to 2-(2,4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1- ylmethyl)]-3-acetyl-5-acetylamino- thiadiazoline ( 2A), using acetic anhydride, and finally hydrolysis3 of (2A) to form 2-(2,4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1- ylmethyl)]-3-acetyl-5-amino-thiadiazoline (3A), using hydrazine hydrate, all compounds having anti-fungal activities, are reported.

DOI: http://dx.doi.org/10.3329/jbcs.v25i1.11765

Journal of Bangladesh Chemical Society, Vol. 25(1), 7-14, 2012

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Published

2012-09-02

How to Cite

Khatun, R., Islam, A. M., & Hai, M. (2012). Synthesis of Schiff Base having a Heterocyclic Moiety along with its Cyclized Derivatives and Study of their Antifungal Activities. Journal of the Bangladesh Chemical Society, 25(1), 7–14. https://doi.org/10.3329/jbcs.v25i1.11765

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