Effects of pretreatment with magnesium sulphate on suxamethonium induced complications during induction of general anaesthesia - A placebo controlled study

Authors

  • Malaya Kumar Das Burn Unit,Dhaka Medical College Hospital, Dhaka
  • Rubina Yasmin National Institute of Ophthalmology and Hospital, Dhaka
  • UH Shahera Khatun Department of Anaesthesia Community Medical College Hospital, Dhaka
  • Md Tanveer Alam Anaesthesiology, Dhaka Medical College Hospital, Dhaka
  • AKM Akhtaruzzaman Department of Anaesthesia, Analgesia & Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Haradhan Debnath Department Of Neurosurgery, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/jbsa.v26i1.19813

Keywords:

Suxamethonium, magnesium sulphate, general anaesthesia, complications

Abstract

Background To administer general anaesthesia with controlled ventilation, laryngoscopy and endotracheal intubation is necessary.Suxamethonium is drug of choice but some side effects preclude its use. Pretreatment with Magnesium sulphate reduces suxamethonium induced complications.

Objective To see the effects of pretreatment with magnesium sulphate on suxamethonium induced complications during induction of general anaesthesia.

Methods A total number of sixty patients of ASA grade I and II were selected randomly as per inclusions and exclusions criteria , thirty in each group. Group- C is the control group and group-M-patients were received magnesium sulphate 60mg per kg. Pulse rate, blood pressure, SPO2, ECG, Serum K+ concentration, fasciculation, myalgia and side effects of magnesium sulphate were recorded.

Results Suxamethnium induced complications like fasciculation, raised potassium concentration, haemodynamic change during intubation and post operative myalgia significantly reduced in patients pre treated with magnesium sulphate.

Conclusion Pretreatment with magnesium sulphate reduces incidence of suxamethonium induced complications during induction of general anaesthesia.

DOI: http://dx.doi.org/10.3329/jbsa.v26i1.19813

Journal of Bangladesh Society of Anaesthesiologists 2013; 26(1): 27-32

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Published

2014-08-03

How to Cite

Das, M. K., Yasmin, R., Khatun, U. S., Alam, M. T., Akhtaruzzaman, A., & Debnath, H. (2014). Effects of pretreatment with magnesium sulphate on suxamethonium induced complications during induction of general anaesthesia - A placebo controlled study. Journal of the Bangladesh Society of Anaesthesiologists, 26(1), 27–32. https://doi.org/10.3329/jbsa.v26i1.19813

Issue

Vol. 26 No. 1 (2013)

Section

Original Articles