Role of oral ondansetron for prevention of postoperative nausea and vomiting in laparoscopy assisted gynaecological surgery - a comparative study

Authors

  • Montosh Kumar Mondal Assistant Professor, Department of Anaesthesiology, National Institute of Cancer Research & Hospital (NICRH), Mohakhali, Dhaka
  • Shahadat Hossain Consultant Anaesthesiologist, Department of Anaesthesiology, Dhaka Dental College, Dhaka
  • Beauty Rani Roy Consultant, Department of Obstetrics and Gynaecology, OGSB Hospital and Institute of Reproductive and Child Health, Mirpur, Dhaka
  • Begum Maksuda Farida MS (Gynae and Obs) thesis part student, Department of Obstetrics and Gynaecology, BSMMU, Shahbag, Dhaka
  • Joysree Roy onsultant, Department of Obstetrics and Gynaecology, Dhaka Medical College, Dhaka
  • AKM Akhtaruzzaman Associate Professor, Department of Anaesthesia, Analgesia and Intensive Care Medicine, BSMMU, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/jbsa.v21i2.3530

Keywords:

Laparoscopy assisted gynaecological surgery, PONV, oral ondansetron, metoclopramide

Abstract

This study was undertaken to find out the efficacy of oral premedication with ondansetron to prevent post-operative nausea and vomiting in diagnostic gynaecological laparoscopy assisted surgery and to compare it with metoclopramide.

We studied fifty patients of ASA physical status I & II, aged between 18-30 years and body weight between 50-60 kgs. The patients were randomized in equal numbers into two groups; Group A patients were received Tab Metoclopramide 10 mg orally an hour before operation and regarded as control and Group B patients were received Tab Ondansetron (0.15 mg/kg) or total 8 mg orally an hour before operation as case. They received a standard general anesthetic. Post-operative analgesia was provided with per rectal diclofenac sodium (50mg). In the recovery room occurrences of nausea and vomiting was assessed for 24 hours. The incidence of nausea was 80% in Group-A, 24% in Group-B (p<0.001) and vomiting was 64% in Group-A, 16% in Group-B (p<0.001). The difference among the groups was statistically significant.

Key words: Laparoscopy assisted gynaecological surgery, PONV, oral ondansetron, metoclopramide.

Journal of BSA, 2008; 21(2): 67-71

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Published

2009-10-09

How to Cite

Mondal, M. K., Hossain, S., Roy, B. R., Farida, B. M., Roy, J., & Akhtaruzzaman, A. (2009). Role of oral ondansetron for prevention of postoperative nausea and vomiting in laparoscopy assisted gynaecological surgery - a comparative study. Journal of the Bangladesh Society of Anaesthesiologists, 21(2), 67–71. https://doi.org/10.3329/jbsa.v21i2.3530

Issue

Vol. 21 No. 2 (2008)

Section

Original Articles