Midazolam and Thiopentone as Co-Induction

Abstract

This study was undertaken to compare the induction characteristics of conventional thiopentone sodium, midazolam, and a combination of midazolam and thiopentone sodium as co-induction agent. Total one hundred and fifty patients of ASA grade I and II were divided into three groups in a double blind randomized study. Group-I received midazolam 0.25 mgkg^-1 intravenously, group-II received thiopentone sodium 5 mgkg^-1 intravenously and Group-III received midazolam 0.1 mg/kg^-1 IV followed by thiopentone sodium 2.5 mg/kg^-1 IV. Induction time was significantly prolonged with midazolam (group-II) compared to thiopentone sodium. The fall in systolic blood pressure (SBP) and diastolic blood pressure (DBP) was clinically insignificant in midazolam group. Induction with midazolam was not smooth and was associated with unwanted movement of limbs. Incidence of apnoea, pain, thrombophlebites were significantly less with midazolam. Co-induction with midazolam and thiopentone significantly reduced the induction time, unwanted movements of limbs, apnoea during induction and cardiovascular stability was also more in co-induction group than thiopenfone sodium group. Incidence and duration of drowsiness was also significantly lesser in coinduction group. These advantages signifies that combination of midazolan and thiopentone is better choice for induction of anaesthesia than the other conventional induction agent like individual midazolam or thiopentone.

DOI: http://dx.doi.org/10.3329/jbsa.v17i1.4047

Journal of BSA, Vol. 17, No. 1 & 2, 2004 p.23-27