Prognostic Value of Serum Troponin I in Sepsis Patients

Authors

  • Syed Tariq Reza Anaesthesiologist, Intensive Care Unit (ICU), Department of Anaesthesia, Analgesia, Palliative & Intensive Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh,
  • Syeda Nusrat Jahan Lecturer, Community Medicine, ShaheedSuhrawardy Medical College, Sher E Banglanagar, Dhaka, Bangladesh
  • AKM Ferdous Rahman Anaesthesiologist, Intensive Care Unit (ICU), Department of Anaesthesia, Analgesia, Palliative & Intensive Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Muhammad Asaduzzaman Anaesthesiologist, Intensive Care Unit (ICU), Department of Anaesthesia, Analgesia, Palliative & Intensive Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Parvin Akhter Associate professor, Department of Anaesthesia, Analgesia, Palliative & Intensive Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Rabeya Begum Associate professor, Department of Anaesthesia, Analgesia, Palliative & Intensive Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Abdur Rahman Ex-Professor & Head, Department of Anaesthesia, Analgesia, Palliative & Intensive Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jbsa.v31i1.66253

Keywords:

prognostic value, troponin I, sepsis

Abstract

Background: Sepsis is one of the leading causes of admission in ICU with high mortality and morbidity.Intensivists face challenges to manage sepsis in their practices particularly in a limited resource setting.The diagnosis of sepsis and its evaluation of severity are not easy because of its complex pathophysiologyand variable nature of presentation. So, researchers identified biomarkers including troponin I for potentialuse in sepsis. Of them troponin I is a useful biomarker with prognostic significance.

Materials and methods: This prospective observational study was conducted among purposively selected110 patients diagnosed as sepsis at intensive care unit (ICU) in Dhaka Medical College & Hospital. Afterfulfilling the inclusion and exclusion criteria, ECG was done to exclude MI. Then troponin I was measuredwith a cut of value of 0.6 ng/ml. the patients were followed up for a period upto 30 days. Statisticalassociations between categorical variables were tested using chi-square test and mean difference ofcontinuous variables by independent t-test. Correlation between troponin I value length of ICU stays andventilator days were calculated.

Results:Among 110 patients diagnosed as sepsis 56.4% had normal troponin I and 43.6% had elevatedtroponin I. Distribution of elevated troponin I was higher among male patients (77.1% vs 64.5%) thanfemale. Mean duration of ICU stay was prolonged in elevated troponin I group as like ventilator support.Positive relationship was found between troponin level I and duration of ventilator support as well aslength of ICU stay (r=0.225, 0.279). There was significantly increased mortality rate in elevated troponingroup of patients compared to normal troponin group (72.9% vs 35.5%) in sepsis patients (p<0.001) followedby in severe sepsis 67.5% vs 35.48% (p=0.001) and 92.9% vs 57.1%) in septic shock (p<0.029).

Conclusion: This study showed that mortality and morbidity increases when troponin I value elevatedin sepsis.

JBSA 2018; 31(1): 12-19

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Published

2018-02-01

How to Cite

Reza, S. T., Jahan, S. N. ., Rahman, A. F. ., Asaduzzaman, M. ., Akhter, P. ., Begum, R. ., & Rahman, A. . (2018). Prognostic Value of Serum Troponin I in Sepsis Patients. Journal of the Bangladesh Society of Anaesthesiologists, 31(1), 12–19. https://doi.org/10.3329/jbsa.v31i1.66253

Issue

Vol. 31 No. 1 (2018)

Section

Original Articles