Journal of Bangladesh Society of Physiologist https://banglajol.info/index.php/JBSP <p>Established in 2006 by the Bangladesh Society of Physiologist Full text articles available.</p><p>Journal of Bangladesh Society of Physiologist is included on <a title="DOAJ" href="https://doaj.org/toc/2219-7508" target="_blank">DOAJ</a>.</p> Bangladesh Society of Physiologist en-US Journal of Bangladesh Society of Physiologist 1995-1213 <p>JBSP retains the copyright of the contents of this journal but grant the readers the right to use the contents with terms and conditions under a creative common attribution licenses 4 of Attribution, Share Alike and Non commercial type(CC BY-NC-SA) that allows copy, distribute, display, and perform the work and make derivative works based on it only for noncommercial purposes.</p><p><a href="http://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license"><img style="border-width: 0;" src="https://i.creativecommons.org/l/by-nc-sa/4.0/88x31.png" alt="Creative Commons Licence" /></a><br />Journal of Bangladesh Society of Physiologist is licensed under a <a href="http://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>. </p> Relationship between CBC and ESR and duration of disease in patients with systemic lupus erythematosus (SLE) https://banglajol.info/index.php/JBSP/article/view/39476 <p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is an autoimmune disease and is associated with considerable morbidity. Hematological abnormalities may be the initial manifestation. Duration may have impact on their hematological parameters.</p> <p><strong>Objective: </strong>To observe the relationship of Complete Blood Count (CBC) and Erythrocyte sedimentation Rate(ESR) with duration of disease in patients with SLE.</p> <p><strong>Methods: </strong>This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2016 to June 2017. Total 60 subjects including both sexes were selected with age ranging from 18 to 55 years. Among them, 30 subjects with SLE were study group and 30 age matched healthy subjects were control group. Total count of RBC, WBC, Platelet and ESR were estimated by automated hematology analyzer. Statistical analysis was done by unpaired Students æt” test, Chi Square test and Pearson’s correlation coefficient (r) test.</p> <p><strong>Results: </strong>In this study, ESR was significantly (p&lt;0.001) higher and RBC,WBC and platelet counts were significantly (p&lt;0.001) lower in SLE patients in comparison to that of control. On correlation analysis, RBC and WBC showed significant negative correlation with duration of disease in patients with SLE.</p> <p><strong>Conclusion: </strong>This study concludes that CBC and ESR were altered in SLE patients and it was related to duration of disease.</p> <p>J Bangladesh Soc Physiol. 2018, December; 13(2): 41-46</p> Mahmuda Abira Qazi Shamima Akhter ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2018-12-26 2018-12-26 13 2 41 46 10.3329/jbsp.v13i2.39476 Effect of Curcuma longa (Turmeric) on serum creatine kinase-MB and troponin I in isoproterenol induced myocardial infarction in wistar albino rats https://banglajol.info/index.php/JBSP/article/view/39477 <p><strong>Background: </strong>The prevalence of myocardial infarction (MI) is increasing day by day in Bangladesh due to socioeconomic transition. Spices and herbs are important source of remedy for various diseases in human. Curcuma longa suggested to be used as an indigenous medicine for the prevention and treatment of cardiovascular disease.</p> <p><strong>Objective: </strong>To observe the effect of Curcuma longa in isoproterenol induced myocardial infarction in Wistar albino rats.</p> <p><strong>Methods: </strong>This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka during 2015. Twenty one Wistar albino male rats, weighing 100 to 150 g (initial body weight); aged 85 to 100 days were selected for the study. After acclimatization for 14 days, the rats were divided into BC (Baseline control group), ISP-TC (Isoproterenol treated control group) and CLP-ISPT (Curcuma longa pretreated and isoproterenol treated group). Each group consisted of 7 rats. After experiment, on the 10th day, final body weight was taken, rats were sacrificed and blood samples were collected from the heart. The heart was removed and weighed. Serum creatine kinase-MB (CK-MB) level was estimated by ELISA method and Troponin I (cTnI) level by AxSYM method. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable.</p> <p><strong>Results: </strong>In this study, the mean percent (%) change of body weight (p&lt;0.01), mean serum CK-MB (p&lt;0.001) and cTnI (p&lt;0.001) levels were significantly higher but mean heart weight was non significantly higher in ISP-TC in comparison to those of BC. Again, the mean percent (%) change of body weight (p&lt;0.01), mean heart weight (p&lt;0.01), mean serum CK-MB (p&lt;0.01) and cTnI (p&lt;0.001) levels were significantly lower in CLP-ISPT than those of ISP-TC group.</p> <p><strong>Conclusion: </strong>From the results, it can be concluded that Curcuma longa may have cardioprotective effect.</p> <p>J Bangladesh Soc Physiol. 2018, December; 13(2): 47-53</p> Sharmin Nahar Qazi Shamima Akhter ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2018-12-26 2018-12-26 13 2 47 53 10.3329/jbsp.v13i2.39477 Serum calcium and serum phosphate levels in transfusion dependent beta thalassemia https://banglajol.info/index.php/JBSP/article/view/39478 <p><strong>Background: </strong>Patients with transfusion dependent beta thalassemia with severeanemia require regular blood transfusion to improve quality of life. This can lead to iron overload which might cause various complications including hypocalcaemia.</p> <p><strong>Objective</strong>: To estimate the serum calcium and phosphate levels in transfusion dependent beta thalassemia patients.</p> <p><strong>Methods: </strong>This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2016 to June 2017. After fulfilling the ethical aspect, a total number of 60 subjects were selected with the age ranging from 5 to 25 years. Among them, 40 transfusion dependent beta thalassemia patients were selected as the study group and 20 age and sex matched apparently healthy individuals were considered as control group for comparison. The study population were selected from Thalassemia foundation hospital, Dhaka. Theserum calcium and phosphate levels were estimated by autoanalyzer.. For statistical analysis, unpaired Student’s‘t’ test, Chi-square test were performed as applicable.</p> <p><strong>Results: </strong>In this study, serum calcium level were significantly (p &lt; 0.001) lower and serum phosphate level were significantly (p &lt; 0.001) higher in transfusion dependent beta thalassemia patients as compared to healthy controls. In addition, 67.5% thalassemia patients had hypocalcemia (calcium level &lt; 8.5 mg/dl) and 85% of thalassemia patients had hyperphosphatemia(phosphate level &gt; 4.7mg/dl).</p> <p><strong>Conclusions: </strong>This study concludes transfusion dependent beta thalassemiapatients have low calcium level and high serum phosphate level which should be monitored to avoid complications related to hypocalcaemia and hyperphosphatemia.</p> <p>J Bangladesh Soc Physiol. 2018, December; 13(2): 54-58</p> Mst Ariza Sultana Qazi Shamima Akhter ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2018-12-26 2018-12-26 13 2 54 58 10.3329/jbsp.v13i2.39478 Anti-diabetic effect of metformin combined with peanut (Arachis hypogaea L.) on streptozotocin induced diabetic rats https://banglajol.info/index.php/JBSP/article/view/39479 <p><strong>Background</strong>: Diabetes mellitus (DM) is a common metabolic disorder. Metformin is the initial drug of choice for treatment of type 2 DM. In many cases, metformin mono-therapy cannot effectively achieve the targeted glycemic control. However, metformin along with peanut (Arachis hypogaea L.) may reduce blood glucose level more effectively.</p> <p><strong>Objective: </strong>To evaluate the anti-diabetic effect of metformin in combination with peanut on streptozotocin induced diabetic rats.</p> <p><strong>Methods: </strong>This experimental study was conducted in the Department of Physiology, Sir Salimullah Medical College, in 2016. Forty (40) Wistar Albino male rats, 90-120 days old, weighing 225-240 g (initial body weight) were taken and divided into four groups containing 10 rats in each group, i.e. Non-diabetic group (ND), Streptozotocin induced diabetic group (STZ), Diabetic group treated with metformin (STZ-M) and Diabetic group treated with metformin and peanut (STZ-MP). Diabetic model was developed by giving single intraperitoneal injection of streptozotocin (50mg/kg body weight) to STZ, STZ-M and STZ-MP groups on day-1. In addition, STZ-M group received metformin (500mg/kg body weight) orally and STZ-MP group received both metformin and peanut extract orally (both 500mg/kg body weight) once daily in the morning for 21 days (day-4 to day-24). After measuring the final body weight, rats were sacrificed on day-25. To observe glycemic status, Fasting Blood Glucose (FBG), serum insulin levels were estimated and HOMA-IR was calculated. Statistical analyses were done by one way ANOVA and Bonferroni test as applicable.</p> <p><strong>Results: </strong>Mean FBG level and HOMA-IR were significantly (p&lt;0.001) higher and serum insulin level and final body weight were significantly (p&lt;0.001) lower in STZ group when compared to those of ND group. Whereas, FBG level and HOMA-IR were significantly (p&lt;0.001) lower and insulin level and final body weight were significantly higher (p&lt;0.001) in both STZ-M and STZ-MP groups in comparison to those of STZ group but more profound effects were found in STZ-MP group than those of STZ-M group.</p> <p><strong>Conclusion: </strong>The present study revealed that, metformin combined with peanut was more effective to control glycemic status in diabetic rats than metformin alone.</p> <p>J Bangladesh Soc Physiol. 2018, December; 13(2): 59-67</p> Shehrina Nazmin Nayma Sultana ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2018-12-26 2018-12-26 13 2 59 67 10.3329/jbsp.v13i2.39479 Effects of exposure to cement dust on hemoglobin concentration and total count of RBC in cement factory workers https://banglajol.info/index.php/JBSP/article/view/39480 <p><strong>Background </strong>: Cement factory workers are exposed to cement dust during their daily work activities. Chronic exposure to cement dust may have adverse effect on the haemopoietic system and the workers would suffer from anemia that may lead to cardiovascular disease.</p> <p><strong>Objective</strong>: To assess the effects of exposure to cement dust on hemoglobin concentration and total count of RBC in cement factory workers.</p> <p><strong>Methods </strong>: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2017 to June 2018. After fulfilling the ethical consideration, 46 apparently healthy male cement factory workers, working in a cement factory for 2 years or more, with age ranging from 20 to 50 years were study group and 46 age, BMI and socioeconomic condition matched apparently healthy male subjects from different areas of Dhaka city were control group. Hemoglobin concentration and total count of RBC were estimated using automated haematology analyzer. For statistical analysis, Unpaired Student’s ‘t’ test and Pearson’s correlation coefficient test were performed.</p> <p><strong>Results</strong>: In this study, hemoglobin concentration and total count of RBC were significantly (<em>p </em>&lt; 0.05) lower in study group than those of control group. Hemoglobin concentration was negatively related with duration of cement dust exposure.</p> <p><strong>Conclusions: </strong>This study concludes that the cement dust exposure had deleterious effect on hemoglobin concentration and total count of RBC and the duration of exposure to cement dust had an impact on hemoglobin concentration.</p> <p>J Bangladesh Soc Physiol. 2018, December; 13(2): 68-72</p> Rahnuma Ahmad Qazi Shamima Akhter ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2018-12-26 2018-12-26 13 2 68 72 10.3329/jbsp.v13i2.39480 The effect of fish oil capsule on serum total cholesterol and triglycride levels in type-2 diabetic patient https://banglajol.info/index.php/JBSP/article/view/39481 <p><strong>Background: </strong>Diabetes Mellitus (DM) is one of the common metabolic disorders that have effects on lipid metabolism. Fish oil supplementation may improve lipid abnormalities in diabetic patient.<strong>Objective: </strong>To observe the effect of supplementation of omega-3 fatty acid on total cholesterol (TC) and triglyceride(TG) level in type 2 DM.</p> <p><strong>Methods: </strong>A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were selected with age 40 to 50 years. Among them, 27 type 2 diabetic patient with supplementation of omega 3 fatty acid (2g/ day) for 12 weeks was considered as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid was considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city.Serum TC and TG were estimated by enzymatic endpoint method in autoanalyzer. The study parameters were measured at base line and after 12 weeks of study period in both groups. For statistical analysis, Paired Student’s‘t’ test and Unpaired Student’s ‘t’ test were performed as applicable using SPSS for windows version 16.0<strong>.</strong></p> <p><strong>Results</strong>: In this study serumTC and TG levels were significantly lower (p&lt;.001) in diabetic patients after supplementation with omega- 3 fatty acid in comparison to that of their baseline value.Again, after 12 weeks, serum TC and TG levels were significantly lower (p&lt;.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. In control group, serum TC and TG levels were almost similar both at baseline and after 3 months of follow-up.</p> <p><strong>Conclusion: </strong>After analyzing the results of the study, it can be concluded that omega-3 fatty acid may improve serum TC and TG levels in type 2 diabetic patient and may be helpful to minimize the complications of type-2 DM.</p> <p>J Bangladesh Soc Physiol. 2018, December; 13(2): 73-77</p> Tamanna Binte Habib Qazi Shamima Akhter ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2018-12-26 2018-12-26 13 2 73 77 10.3329/jbsp.v13i2.39481 Reliability and patentability of academic-rank promotional criteria in medical colleges of India https://banglajol.info/index.php/JBSP/article/view/39485 <p>A promotion refers to the progress of an employee’s position or ranks in a hierarchical constitution with an increase in status, responsibilities, and salary<strong>. </strong>Academic rank Promotional criteria considered by the Medical Council of India (MCI) include educational qualifications, seniority according to years of teaching experience and numbers of Publications. There is gap between faculty role in medical college and expectation for promotion in India. Impractical expectation beyond the self-competency has promoted unethical practices. The various scientific misconduct problems had faded the quality of research in India. So the expected criteria for the evaluation of faculty members are needed to be re-adjusted by policymakers, according to the facilities of the scientific centers and human, social and economic resources at the institute. Medical Council of India needs to evolve and implement a suitable promotional policy for faculty members of medical colleges in India.</p> <p>J Bangladesh Soc Physiol. 2018, December; 13(2): 78-83</p> Smita Rameshrao sorte Sachin Babu Rathod ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2018-12-26 2018-12-26 13 2 78 83 10.3329/jbsp.v13i2.39485 Erratum: Effect of Nigella sativa (Kalozira) oil on pain in Long Evans rats. J Bangladesh Soc Physiol 2018, June;13(1):1-7 https://banglajol.info/index.php/JBSP/article/view/39486 <p>The author of this article brought attention to publishers that there were errors on page 1,3,4,5 published in previous issue. These errors have been corrected to enhance credibility to readers and the whole corrected article has been published in this issue of JBSP.</p> <p>The online version of the original article can be found at doi:http:/ /dx.doi.org/10.3329/jbsp,v13i1.37840(http://banglajol.info/ index.php/JBSP/article/view/37840)</p> <p><strong>Background: </strong>For thousands of years, <em>Nigella sativa </em>has been used in many countries as a spice as well as a protective and curative remedy for numerous health disorders. <em>Nigella sativa </em>oil (NSO) suppressed pain in animal models.</p> <p><strong>Objective: </strong>To assess the effects of <em>Nigella sativa </em>oil on pain after single administration with three increasing doses in rat models.</p> <p><strong>Methods: </strong>This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2016 to February 2017. For this, 20 (twenty) Long Evans rats (200±20) of both sexes were divided into control ( 10 ml/kg of 1% solution of Tween 20) and experimental groups (NSO 0.5, with 0.5 ml/kg NSO; NSO 1, with 1 ml/kg NSO; NSO 1.5, with 1.5 ml/kg NSO) with 5 rats in each group. To assess nociceptive pain, central analgesic system and inflammatory pain early phase (1<sup>st</sup>-5<sup>th</sup> minutes); inter phase (6th-15th minutes) and late phase (16th-60th minutes) of formalin test respectively were observed. All the agents were given intraperitoneally in a single dose just one hour before the formalin test. In all phases, total frequency of jerking and total duration of flexing and licking of right hind paw were counted after administration of subcutaneous formalin (50 mL, 2.5%) injection. Statistical analysis was done by ANOVA, followed by Bonferroni’s post hoc test.</p> <p><strong>Results: </strong>In early phase, NSO significantly reduced the jerking (p ≤0.001, in all doses) and flexing and licking (p ≤0.001, in higher 2 doses). In interphase, jerking was significantly (p ≤0.01) lowered after 1.5 ml/kg of NSO but flexing and licking significantly lowered by all 3 doses (p ≤0.05, p ≤ 0.001, p≤ 0.001). In addition, in late phase jerking and flexing and licking was reduced by higher 2 doses (p ≤0.001) and all 3 doses respectively (p ≤ 0.001, in all doses).</p> <p><strong>Conclusion: </strong>From this study, it may be concluded that, NSO possess analgesic effect and higher two doses were more effective than lower doses.</p> <p>J Bangladesh Soc Physiol. 2018, December; 13(2): 84-90</p> Ismat Ara Jerin Noorzahan Begum ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2018-12-26 2018-12-26 13 2 84 90 10.3329/jbsp.v13i2.39486