TY - JOUR AU - Diba, Farah AU - Karim, Md. Anwarul AU - Soma, Shahinoor Akter AU - Chowdhury, Indira AU - Mamun, Showkat AU - Mondal, Md. Nazrul Islam PY - 2021/03/23 Y2 - 2024/03/29 TI - Immunophenotypic Pattern and Treatment Outcome after Completion of Induction Remission in Children with Acute Lymphoblastic Leukemia JF - Journal of Current and Advance Medical Research JA - J Curr Adv Med Res VL - 8 IS - 1 SE - Original Articles DO - 10.3329/jcamr.v8i1.52596 UR - https://banglajol.info/index.php/JCAMR/article/view/52596 SP - 59-64 AB - <p><strong>Background</strong>: Acute lymphoblastic leukemia (ALL) is presented with different immunophenotypic pattern.</p><p><strong>Objective:</strong> The purpose of the study was to evaluate the immunophenotypic pattern of ALL and also, to recognize the frequency of different ALL subtypes and treatment outcome after induction remission therapy.</p><p><strong>Methodology:</strong> This prospective study was conducted in the Department of Paediatric Hematology and Oncology at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from June 2017 to July 2018 for a period of one year. Newly diagnosed admitted cases of ALL aged 1 to 17.9 years were included. Immunophenotyping from aspirate marrow samples were done in a special hematology laboratory. Patients were monitored during induction remission period with physical examination and required investigations.</p><p><strong>Result</strong>: Among 87 analyzed patients, 81 patients (93.1%) were B-cell ALL and 6 patients (6.9%) were T-cell ALL. After completion of induction remission therapy 61 patients had undergone complete remission and among them B cell ALL were 56(69.1%) and T cell were 5(83.3%) (P=0.464). None of the patient had partial response or induction failure. Complication were developed in 53(60.91%) patients during induction therapy. Most common cause of death was septicemia (22/26). Death was more in patients who had total WBC count &gt;50X10<sup>9</sup>/L (p=0.017) and received regimen B (p=0.031).</p><p><strong>Conclusion:</strong> B cell ALL was more common and most of the patients had undergone complete remission after induction remission therapy.</p><p><em>Journal of Current and Advance Medical Research, January 2021;8(1):59-64</em></p> ER -