Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study

Authors

  • Md. Aminul Haque Khan Department of Biochemistry, Enam Medical College, Savar, Dhaka
  • Md. Ishaque Majumder Department of Medicine, Sir Salimullah Medical College, Dhaka
  • Md. Mozammel Hoque Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Md. Fariduddin Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Forhadul Hoque Mollah Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Iqbal Arslan Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka

DOI:

https://doi.org/10.3329/jemc.v3i2.16129

Keywords:

Hypothyroidism, Creatinine, Uric acid, Hyperuricemia,

Abstract

Background: Hypothyroidism is associated with many biochemical abnormalities including increased serum creatinine and uric acid levels. Many studies were done abroad regarding serum creatinine and uric acid levels in hypothyroid patients. We designed this study in our population for evaluation of serum creatinine and uric acid levels in hypothyroid patients.

Objective: To assess serum creatinine and uric acid levels in hypothyroid patients and to find out relationship of creatinine and uric acid levels with severity of hypothyroidism.

Materials and Methods: This retrospective cross sectional study to evaluate the serum creatinine and uric acid levels of hypothyroid patients and to find out relationship of hyperuricemia and hypercreatininemia with severity of hypothyroidism was done in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka. Results were compared with that of age and sex matched healthy euthyroid controls. Statistical analyses were performed by using SPSS for Windows version 10.0. ANOVA and unpaired t tests were done to see the significance among the groups and between groups respectively. Pearsons correlation coefficient test was done to see the correlation of serum creatinine and uric acid levels with the severity of hypothyroidism.

Results: Mean serum creatinine and uric acid levels in cases were 1.38 ± 0.53 and 7.00 ± 2.54 mg/dL respectively compared to 1.01 ± 0.17 and 5.21 ± 1.35 mg/dL in controls.

Conclusion: Mean serum creatinine and uric acid levels were found significantly higher in hypothyroid patients compared to controls. These findings suggest that hyperuricemia and hypercreatininemia are associated with hypothyroidism. Therefore, patients presenting with these biochemical abnormalities are recommended to be investigated to explore hypothyroidism.

Journal of Enam Medical College; Vol 3 No 2 July 2013; Page 84-87

DOI: http://dx.doi.org/10.3329/jemc.v3i2.16129

Downloads

Download data is not yet available.
Abstract
424
PDF
334

Downloads

Published

2013-08-07

How to Cite

Khan, M. A. H., Majumder, M. I., Hoque, M. M., Fariduddin, M., Mollah, F. H., & Arslan, I. (2013). Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study. Journal of Enam Medical College, 3(2), 84–87. https://doi.org/10.3329/jemc.v3i2.16129

Issue

Vol. 3 No. 2 (2013)

Section

Original Articles

License

  • Copyright on any research article is transferred in full to Journal of Enam Medical College upon publication in the journal. The copyright transfer includes the right to reproduce and distribute the article in any form of reproduction (printing, electronic media or any other form).
  • Articles in the Journal of Enam Medical College are Open Access articles published under the Creative Commons CC BY License (https://creativecommons.org/licenses/by/4.0/)
  • This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.