GeneXpert MTB/RIF Assay for Rapid Identification of Mycobacterium Tuberculosis and Rifampicin Resistance Directly from Sputum Sample

Authors

  • Nourjahan Laskar Assistant Professor, Department of Microbiology, International Medical College, Gazipur
  • Md Akram Hossain Professor, Department of Microbiology, Mymensingh Medical College, Mymensingh
  • Jannatul Fardows Assistant Professor, Department of Microbiology, Kumudini Women?s Medical College, Tangail
  • Mominur Rahman Registrar, Department of Neuroanaesthesia and Neuro ICU, Apollo Hospitals, Dhaka

DOI:

https://doi.org/10.3329/jemc.v7i2.32653

Keywords:

GeneXpert assay, MDR TB, Sensitivity, Specificity

Abstract

Background: The World Health Organization has endorsed the use of molecular methods for the detection of tuberculosis (TB) and drug resistant TB as a rapid method. In Bangladesh, the Xpert MTB/RIF assay has been implemented into reference laboratories for diagnosis of TB and also MDR TB.

Objective: Drug resistant tuberculosis has long been a common problem prevailing in our country. The present study focused on the rapid identification of Mycobacterium tuberculosis as well as drug resistance.

Materials and Methods: Sputum samples from a total of 107 cases, assumed as multi-drug resistance tuberculosis, were studied through GeneXpert assay.

Results: Out of 107 cases, 91 (85.05%) were detected having M. tuberculosis ? 64 (59.81%) were rifampicin sensitive and 27 (25.23%) were rifampicin resistant. The sensitivity and specificity of the GeneXpert are 87.64% and 75% respectively.

Conclusion: GeneXpert assay can be considered for the rapid diagnosis of drug resistant tuberculosis.

J Enam Med Col 2017; 7(2): 86-89

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Author Biography

Nourjahan Laskar, Assistant Professor, Department of Microbiology, International Medical College, Gazipur



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Published

2017-06-04

How to Cite

Laskar, N., Hossain, M. A., Fardows, J., & Rahman, M. (2017). GeneXpert MTB/RIF Assay for Rapid Identification of Mycobacterium Tuberculosis and Rifampicin Resistance Directly from Sputum Sample. Journal of Enam Medical College, 7(2), 86–89. https://doi.org/10.3329/jemc.v7i2.32653

Issue

Vol. 7 No. 2 (2017)

Section

Original Articles

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