@article{Rahman_Jahan_Habib_Sultana_Sultana_Paul_Bhowmik_Begum_2012, title={Raised Vaginal Fluid Fibronectin Level Indicates Premature Rupture of Membrane}, volume={2}, url={https://banglajol.info/index.php/JEMC/article/view/12841}, DOI={10.3329/jemc.v2i2.12841}, abstractNote={<p><strong>Background: </strong>Premature rupture of membrane (PROM) is one of the common complications  of pregnancy that has major impact on fetal and neonatal outcome. It is the commonest  clinical event where a normal pregnancy becomes suddenly a high-risk one for mother and  fetus or neonate. <strong></strong></p><p><strong>Objective: </strong>The study was undertaken to investigate whether raised  fibronectin level in vaginal fluid may indicate premature rupture of membrane. <strong></strong></p><p><strong>Materials and  Methods: </strong>This cross sectional study was conducted in the department of Obstetrics and  Gynecology in Sir Salimullah Medical College & Mitford Hospital, Dhaka during the period  of January 2006 to December 2007. A total of 114 pregnant women with gestational age 28th  week up to 40th week were included. Sixty were PROM (Group I) and 54 were non-PROM  (Group II) subjects. Fibronectin in vaginal fluid was measured by an immunochemical  reaction by nephelometer. Statistical analysis was done by SPSS version 10.0. <strong></strong></p><p><strong>Results: </strong>The  PROM patients had significantly higher concentration of fibronectin (225.77 ± 115.18 ng/mL)  compared to that in non-PROM subjects (8.04 ± 16.17 ng/mL) (p < 0.001). <strong></strong></p><p><strong>Conclusion: </strong>It  can be concluded that in cases of unequivocal rupture or intactness of the membranes, the  result of the fibronectin test corresponds well with the clinical situation. So fibronectin is a  sensitive test for detection of amniotic fluid in the vagina.</p> <p>DOI: <a href="http://dx.doi.org/10.3329/jemc.v2i2.12841">http://dx.doi.org/10.3329/jemc.v2i2.12841</a></p> <p>J Enam Med Col 2012; 2(2): 74-79</p>}, number={2}, journal={Journal of Enam Medical College}, author={Rahman, Shamima and Jahan, Samsad and Habib, Samira Humaira and Sultana, Nasrin and Sultana, Mst Nigar and Paul, Debashish and Bhowmik, Amrita and Begum, Khodeja}, year={2012}, month={Dec.}, pages={74–79} }