Protective Effect of Fish Oil Supplementation on DNA Damage Induced by Cigarette Smoking

Authors

  • Amir Ghorbanihaghjo Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz
  • Javid Safa Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz
  • Samira Alizadeh Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz
  • Hassan Argani Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz
  • Nadereh Rashtchizadeh Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz
  • Mohammad Vahid Taghinia Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz
  • Mehran Mesgari Abbasi Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz

DOI:

https://doi.org/10.3329/jhpn.v31i3.16826

Keywords:

8-hydroxy-2’-deoxyguanosine, Antioxidants, Cigarette smoking, Fish oil

Abstract

The study examined the influence of fish oil (FO) supplementation on serum 8-hydroxy-2-deoxyguanosine (8-OHdG) levels as indicated by DNA damage markers and total antioxidant capacity (TAC) among male cigarette smokers. This double-blind, placebo-controlled randomized study was conducted among healthy cigarette smokers (n=40) who were part of a larger prospective cohort study. Twenty smokers were randomly selected to receive FO for 3 months (1 g/day), and another 20 smokers received a placebo for 3 months; 8-OHdG and TAC levels were measured in blood samples before and after the intervention. Serum 8-OHdG significantly decreased (p=0.001) and TAC increased (p<0.001) after 3 months of treatment with FO. Between baseline and endline, the difference in 8-OHdG significantly correlated with the difference in TAC among smokers who received FO (r=-0.540, p=0.014). The study provides evidence that FO supplementation can modify decreased antioxidants and increased oxidative DNA damage in cigarette smokers.

DOI: http://dx.doi.org/10.3329/jhpn.v31i3.16826

J HEALTH POPUL NUTR 2013 Sep; 31(3): 343-349

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Published

2013-11-03

How to Cite

Ghorbanihaghjo, A., Safa, J., Alizadeh, S., Argani, H., Rashtchizadeh, N., Taghinia, M. V., & Abbasi, M. M. (2013). Protective Effect of Fish Oil Supplementation on DNA Damage Induced by Cigarette Smoking. Journal of Health, Population and Nutrition, 31(3), 343–349. https://doi.org/10.3329/jhpn.v31i3.16826

Issue

Vol. 31 No. 3 (2013)

Section

Original Papers