Economic Impact of a Rotavirus Vaccine in Brazil

Authors

  • Dagna O Constenla Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
  • Alexandre C Linhares Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Av. Almirante Barroso 492, 66090-000 Belém, Pará, Brasil
  • Richard D Rheingans Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
  • Lynn R Antil Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
  • Eliseu A Waldman Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP 01246-904, Brasil
  • Luiz J da Silva Disciplina de Infectologia, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, 13083-970, Brasil

DOI:

https://doi.org/10.3329/jhpn.v26i4.1880

Keywords:

Costs and cost analysis, Diarrhoea, Infantile, Gastroenteritis, Morbidity, Rotavirus, Rotavirus vaccines, Vaccination, Brazil

Abstract

The study was done to evaluate the cost-effectiveness of a national rotavirus vaccination programme in Brazilian children from the healthcare system perspective. A hypothetical annual birth-cohort was fol­lowed for a five-year period. Published and national administrative data were incorporated into a model to quantify the consequences of vaccination versus no vaccination. Main outcome measures included the reduction in disease burden, lives saved, and disability-adjusted life-years (DALYs) averted. A rotavirus vac­cination programme in Brazil would prevent an estimated 1,804 deaths associated with gastroenteritis due to rotavirus, 91,127 hospitalizations, and 550,198 outpatient visits. Vaccination is likely to reduce 76% of the overall healthcare burden of rotavirus-associated gastroenteritis in Brazil. At a vaccine price of US$ 7-8 per dose, the cost-effectiveness ratio would be US$ 643 per DALY averted. Rotavirus vaccination can reduce the burden of gastroenteritis due to rotavirus at a reasonable cost-effectiveness ratio.

Key words: Costs and cost analysis; Diarrhoea, Infantile; Gastroenteritis; Morbidity; Rotavirus; Rotavirus vaccines; Vaccination; Brazil

doi:10.3329/jhpn.v26i4.1880

J Health Popul Nutr 2008 Dec:26(4):388-396

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Author Biography

Dagna O Constenla, Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

Dr. Dagna Constenla
Department of Global Health
Rollins School of Public Health
Emory University
Atlanta, GA
USA
Email: dagnaconstenla@yahoo.com
Cover of JHPN Vol.26(4)

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How to Cite

Constenla, D. O., Linhares, A. C., Rheingans, R. D., Antil, L. R., Waldman, E. A., & da Silva, L. J. (2009). Economic Impact of a Rotavirus Vaccine in Brazil. Journal of Health, Population and Nutrition, 26(4), 388–396. https://doi.org/10.3329/jhpn.v26i4.1880

Issue

Vol. 26 No. 4 (2008)

Section

Original Papers