Drug-susceptibility Patterns of <i>Mycobacterium tuberculosis</i> in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen

Authors

  • E Green AIDS Virus Research Laboratory, Department of Microbiology, University of Venda and Department of Biochemistry and Microbiology, University of Fort Hare
  • CL Obi Research and Academic Directorate, Walter Sisulu University, Mthatha
  • M Nchabeleng Deparment of Medical Microbiology, University of Pretoria (Deceased)
  • BE de Villiers Deparment of Medical Microbiology, University of Pretoria
  • PP Sein Deparment of Medical Microbiology, University of Pretoria
  • T Letsoalo Deparment of Medical Microbiology, University of Pretoria
  • AA Hoosen Deparment of Medical Microbiology, University of Pretoria
  • PO Bessong AIDS Virus Research Laboratory, Department of Microbiology, University of Venda
  • RN Ndip Department of Biochemistry and Microbiology, University of Fort Hare and Department of Biochemistry and Microbiology, University of Buea, Cameroon

DOI:

https://doi.org/10.3329/jhpn.v28i1.4518

Keywords:

Drug resistance, Microbial, Mycobacterium tuberculosis, Risk factors, Tuberculosis, South Africa

Abstract

 Multidrug-resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. The prevalence of drug resistance in Mycobacterium tuberculosis (MTB) isolates (n=692) from Mpumalanga province was assessed. In total, 692 (64%) MTB strains from cases with pulmonary TB were tested for susceptibility against rifampicin, isoniazid, ethambutol, and streptomycin using the MGIT 960 instrument. Two hundred and nine (30.2%) strains were resistant to one or more drugs. Resistance to one drug ranged from 1.4% for ethambutol to 17.7% for rifampicin. The prevalence of MDR-TB ranged from 6.7% for three drugs to 34% for four drugs, with significant predictors being patients' age-groups of 25-54 years (p=0.0012) and >55 years (p=0.007). The result showed a high level (58.4%) of MDR-TB from cases in Mpumalanga province. To achieve a higher cure rate in this province, drug-susceptibility tests must be done for every case.

Key words: Drug resistance; Microbial; Mycobacterium tuberculosis; Risk factors; Tuberculosis; South Africa

DOI: 10.3329/jhpn.v28i1.4518

J Health Popul Nutr 2010 Feb; 28(1): 7-13

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How to Cite

Green, E., Obi, C., Nchabeleng, M., de Villiers, B., Sein, P., Letsoalo, T., Hoosen, A., Bessong, P., & Ndip, R. (2010). Drug-susceptibility Patterns of <i>Mycobacterium tuberculosis</i> in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen. Journal of Health, Population and Nutrition, 28(1), 7–13. https://doi.org/10.3329/jhpn.v28i1.4518

Issue

Vol. 28 No. 1 (2010)

Section

Original Papers