Antitubercular Drug Resistance in Four Healthcare Facilities in North India

Authors

  • Anamika Gupta Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi
  • Jitendra Prasad Mathuria Department of Microbiology, Manipal College of Medical Sciences, Pokhara
  • Surya Kumar Singh Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi
  • Anil Kumar Gulati Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi
  • Shampa Anupurba Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi

DOI:

https://doi.org/10.3329/jhpn.v29i6.9895

Keywords:

Acquired immunodeficiency syndrome, Antitubercular drugs, Diabetes, Drug resistance, HIV, Tuberculosis, India

Abstract

Tuberculosis (TB) is a major public-health problem in India, having the highest number of incident and multidrug-resistant (MDR) TB cases. The study was carried out to appraise the prevalence of first-line anti- TB drug resistance in Mycobacterium tuberculosis (MTB) and its patterns among different types of TB patients from different settings in a province of North India. Of 3,704 clinical specimens, 345 (9.3%) were culturepositive, and drug-susceptibility testing was carried out for 301 MTB strains. A high level of primary and acquired drug resistance of MTB was observed in the region studied, with weighted mean of 10.5% and 28.08%, 12.81% and 29.72%, 17.12% and 29.94%, 11.97% and 27.84%, and 10.74% and 23.54% for rifampicin, isoniazid, streptomycin, ethambutol-resistant and MDR cases respectively. Drug resistance was significantly higher in pulmonary (p=0.014) and acquired drug-resistant TB cases (p<0.001). Any drug resistance (p=0.002) and MDR TB were significantly (p=0.009) associated with HIV-seropositive cases. An urgent plan is needed to continuously monitor the transmission trends of drug-resistant strains, especially MDR-TB strains, in the region.

DOI: http://dx.doi.org/10.3329/jhpn.v29i6.9895

JHPN 2011; 29(6): 583-592

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How to Cite

Gupta, A., Mathuria, J. P., Singh, S. K., Gulati, A. K., & Anupurba, S. (2012). Antitubercular Drug Resistance in Four Healthcare Facilities in North India. Journal of Health, Population and Nutrition, 29(6), 583–592. https://doi.org/10.3329/jhpn.v29i6.9895

Issue

Vol. 29 No. 6 (2011)

Section

Original Papers