Serum Creatinine Levels in Children and Adolescents with Type-1 Diabetes Mellitus and its Relationship with Glycemic Control: An Experience from A Tertiary Level SpecializedHospital in Bangladesh

Abstract

Background: Type 1 Diabetes Mellitus (T1DM) is a chronic condition that can lead to multiple complications, including diabetic nephropathy. Serum creatinine is a common biomarker for assessing renal function and it is also important to understand how glycemic control influences creatinine levels in T1DM patients.

Objective: This study aims to estimate the serum creatinine level and its relationship with the glycemic control in children and adolescents with Type 1 Diabetes Mellitus.

Methodology: For this study, 80 type 1 diabetic children & adolescents with age range 1 to 18 years and 80 age-matched healthy controls were enrolled from the outpatient department of BIRDEM General Hospital-2, Dhaka, Bangladesh, during July 2016 to June 2017. Using a cross-sectional design, we measured anthropometric parameters and serum creatinine levels of all study subjects. Glycemic control was evaluated through estimation of HbA1c.

Results: The mean serum creatinine levels were significantly higher in patients with type 1 DM compared to controls (1.1 ± 0.5 vs. 0.8 ± 0.2 mg/dl; P < 0.001). Higher levels of creatinine were found in subjects with poor glycemic control compared to good glycemic control (1.2 ± 0.5 vs. 0.9 ± 0.4 mg/dl; P<0.05).

Conclusion: Serum creatinine level is higher in type 1 diabetic children & adolescents in comparison to their healthy counterparts, and this higher creatinine level is strongly associated with poor glycemic control, which may potentially contribute to the early development of diabetic complications.

Journal of Monno Medical College December, 2025;11(2):86-90