Changes in Glomerular Filtration Rate and Its Relation to Serum Calcium Level in Advanced Stages of Chronic Kidney Disease

Authors

  • Gobinda Chandra Saha Associate Professor, Department of Physiology, Sher-E-Bangla Medical College, Barisal
  • M Akhtaruzzaman Associate Professor, Department of Biochemistry, National Institute of Neuroscience & Hospital, Dhaka
  • Ekramul Mustafa Lecturer, Department of Physiology, Dhaka Medical College, Dhaka
  • Asif Mahmud Lecturer, Department of Pharmacology, Dr. Sirajul Islam Medical College, Dhaka
  • Sunil Kumar Sikder Assistant Professor, Department of Oncology, Faridpur Medical College, Faridpur

DOI:

https://doi.org/10.3329/jninb.v1i1.22942

Keywords:

CKD, GFR, serum creatinine, serum calcium

Abstract

Background: The progression of CKD occurs in five different stages in which there are gradual changes of GFR, serum creatinine and serum calcium.

Objective: The study was undertaken to determine GFR in advanced stages of CKD and its relation with s. creatinine and s. calcium and also to find out the correlation between s. creatinine and s. calcium.

Methodology: This study was carried out in the departments of Physiology and Nephrology, Rajshahi Medical College. All the advanced stage chronic kidney disease patients were taken as comparison. Apparently healthy persons were taken as control. Serum Creatinine was measured by alkaline picrate method; estimation of GFR was done by using Cockcroft- Gault formula and serum calcium was performed by analyzer.

Result: In this study a total number of 120 subjects were included, out of which 30 were healthy control and 90 were diagnosed cases of advanced stages of CKD. Among the patients, 55 (61.12%) were male and 35 (38.88%) were female. Mean age (±SD) of the patients were 45 ± 11.16 (Range 20-65 years). While comparing between groups of CKD patients, it was found that s. creatinine of control group was significantly lower than that of group 1. Again s. creatinine of Group 1 was significantly lower than that of group 2 and similarly, s. creatinine of group 2 was significantly lower than that of group 3. On the other hand, s. calcium of control group was significantly higher than group 1, likewise s. calcium of group 1 was significantly higher than that of group 2 and s. calcium of group 2 was significantly higher than that of group 3.

Conclusion: From this study the inference could be drawn that serum calcium had a positive correlation with GFR and a negative correlation with s. creatinine.

J. Natl Inst. Neurosci Bangladesh 2015;1(1):15-17

Downloads

Download data is not yet available.
Abstract
282
PDF
117

Author Biography

Gobinda Chandra Saha, Associate Professor, Department of Physiology, Sher-E-Bangla Medical College, Barisal



Downloads

Published

2015-04-28

How to Cite

Saha, G. C., Akhtaruzzaman, M., Mustafa, E., Mahmud, A., & Sikder, S. K. (2015). Changes in Glomerular Filtration Rate and Its Relation to Serum Calcium Level in Advanced Stages of Chronic Kidney Disease. Journal of National Institute of Neurosciences Bangladesh, 1(1), 15–17. https://doi.org/10.3329/jninb.v1i1.22942

Issue

Vol. 1 No. 1 (2015)

Section

Original Research Articles

License

Copyright on any research article in the Journal of National Institute of Neurosciences Bangladesh is retained by the author(s).

The authors grant the National Institute of Neurosciences Bangladesh a license to publish the article and identify itself as the original publisher.

Articles in the Journal of National Institute of Neurosciences Bangladesh are Open Access articles published under the Creative Commons CC BY-NC License (https://creativecommons.org/licenses/by-nc/4.0/)

This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and it is not used for commercial purposes.