Relationship of Central Post-Stroke Pain with Location and Type of Lesions in Brain among Thalamic Stroke Patients

Authors

  • Mohammad Sadekur Rahman Sarkar Assisstant Professor, Department of Neurlogy, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
  • Mashfiqul Hasan Assistant Professor, Department of of Endocrinoology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
  • Md Badrul Alam Joint Director & Professor of Neurology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
  • Mansur Habib Former Head & Professor of Neurology, Dhaka Medical College & Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jninb.v8i1.59925

Keywords:

Central Post-Stroke Pain; CPSP; thalamic stroke; location; type of lesions

Abstract

Background: Central post-stroke pain (CPSP) is a neuralgic pain syndrome following a stroke in thalamic region.

Objective: The purpose of the present study was to see the relationship of Central Post-Stroke Pain with Location and Type of Lesions in Brain among Thalamic Stroke Patients.

Methodology: This analytical cross-sectional study was carried out in the Department of Neurology at Dhaka Medical College and Hospital, Dhaka, Bangladesh during July 2013 to June 2015 for a period of two years. Patients with CPSP and without CPSP with isolated thalamic stroke within one year of event who were communicable with sufficient cognitive function were selected as study population. Demographic variables and clinical features were recorded by face to face interview, examination and by evaluating medical records. Pain perception was tested with the use of pinprick; temperature sense was tested with a cold tuning fork. Intensity of pain was graded on visual analogue scale (VAS).

Results: This study was included 100 patients of which 50 cases were with CPSP and 50 cases were without CPSP. The mean age with SD of the study population were 57.2±11.4 years. 46% female, with isolated thalamic stroke. There was no significant difference between CPSP and non-CPSP groups in relation to age (p>0.05), gender ((p>0.05), area of living (p>0.05) or frequency of risk factors (p>0.05). Frequency of participants with impairment of pain and thermal sensation as well as allodynia and dysesthesia were significantly higher in CPSP group in comparison to those in non-CPSP group (p<0.05 for all). Most of the participants with CPSP developed pain within one month of stroke event (60.0%), and had burning type of pain (74.0%). Majority of participants had moderate pain (56%), followed by severe and mild pain, 24% and 20% respectively. Participants with right sided lesion had higher risk of CPSP (OR 3.4; 95% CI 1.5-8.4; p=0.003) in comparison to those with lesions in the left. Similarly, participants with ischemic stroke had higher risk of CPSP (OR 3.5; 95% CI 1.4-9.0; p=0.007) in comparison to those with hemorrhagic stroke.

Conclusions: Right sided lesions are more commonly found among subjects with CPSP and thalamic ischemia is more vulnerable than thalamic hemorrhage to develop CPSP after thalamic stroke.

Journal of National Institute of Neurosciences Bangladesh, January 2022; 8(1):9-13

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Published

2022-05-27

How to Cite

Rahman Sarkar, M. S., Hasan, M. ., Alam, M. B. ., & Habib, M. (2022). Relationship of Central Post-Stroke Pain with Location and Type of Lesions in Brain among Thalamic Stroke Patients. Journal of National Institute of Neurosciences Bangladesh, 8(1), 9–13. https://doi.org/10.3329/jninb.v8i1.59925

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Section

Original Research Articles