Role of Booster Dose on Antibody Titer after Recombinant Hepatitis B Vaccination

Authors

  • Md Abdul Ahad Assistant Professor, Department of Gastroenterology, Rajshahi Medical College
  • Md Abdul Alim Assistant Professor, Department of Gastroenterology, Rajshahi Medical College
  • Abhijit Guho Medical Officer, Department of Microbiology, Rajshahi Medical College
  • Quazi Tarikul Islam Professor and Head, Department of Medicine, Rajshahi Medical College
  • Khan Abul Kalam Azad Professor, Department of Medicine. Dhaka Medical College, Dhaka

DOI:

https://doi.org/10.3329/jom.v10i2.2817

Keywords:

Hepatitis B vaccine

Abstract

Hepatitis B virus infection is an important public health problem with significant morbidity and mortality. Recombinant hepatitis B vaccination for the prevention of hepatitis B virus infection is in practice in different parts of the world since its availability in 1986. Government of Bangladesh has also included hepatitis B vaccine in EPI schedule since 2005. This study was carried out to assess the seroconversion status among hepatitis B vaccinated individuals. A total of 190 individuals including 150 vaccinated persons and 40 non-vaccinated apparently healthy individuals were included as study population. Sources of vaccinated persons were from both EPI and non-EPI schedule of vaccination. Age and sex matched non-vaccinated individuals served as controls for the study. All individuals constituting the study population were screened for HBsAg by Immunochromatographic strip test and only HBsAg-negative persons were included for estimation of their anti-HBs titer. Out of 150 vaccinated individuals, 133(88.67%) were found to have anti-HBs titer in the protective level (e"10 IU/L), while 17(11.33%) individuals had anti-HBs titer below the protective level (<10 IU/L). All non-vaccinated controls had anti- HBs titers below the protective level. Immune response developed among vaccinated individuals, 67.78%, 23.33% and 8.89% were good-responders, hypo-responders and non-responders respectively. Mean titer of anti-HBs was found significantly higher among recipients who received booster dose than those who received 3 doses schedule (863.39 IU/L vs. 262.40 IU/L), indicating high antibody titer develops after booster dose. Vaccinated group included 85 (56.67%) men and 65 (43.33%) women with protective level of anti-HBs titer found in 85.88% male and 92.31% female individuals.  

doi: 10.3329/jom.v10i2.2817

J MEDICINE 2009; 10 : 67-76

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Author Biography

Md Abdul Ahad, Assistant Professor, Department of Gastroenterology, Rajshahi Medical College

Assistant Professor, Department of Gastroenterology, Rajshahi Medical
College, Bangladesh

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How to Cite

Ahad, M. A., Alim, M. A., Guho, A., Islam, Q. T., & Azad, K. A. K. (2009). Role of Booster Dose on Antibody Titer after Recombinant Hepatitis B Vaccination. Journal of Medicine, 10(2), 67–76. https://doi.org/10.3329/jom.v10i2.2817

Issue

Vol. 10 No. 2 (2009)

Section

Original Articles

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