IL-2, IFN-?³ and anti-HBs based Immune Responses to Hepatitis B Vaccine in Type 2 Diabetic Patients

Authors

  • Ashesh Kumar Chowdhury Department of Immunology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorder (BIRDEM), 122- Kazi Nazrul Islam Avenue, Shahbag, Dhaka-1000
  • Sujal Kumar Bokshi Department of Immunology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorder (BIRDEM), 122- Kazi Nazrul Islam Avenue, Shahbag, Dhaka-1000
  • Zeenat Farzana Rahman Department of Immunology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorder (BIRDEM), 122- Kazi Nazrul Islam Avenue, Shahbag, Dhaka-1000
  • Md Abu Taher Department of Immunology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorder (BIRDEM), 122- Kazi Nazrul Islam Avenue, Shahbag, Dhaka-1000
  • Subhagata Choudhury Director Laboratory Sevices, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorder (BIRDEM), 122- Kazi Nazrul Islam Avenue, Shahbag, Dhaka-1000

DOI:

https://doi.org/10.3329/jom.v17i1.30051

Keywords:

Anti-HBs, IL-2, IFN-?, Hepatitis B Vaccine, Type 2 Diabetes

Abstract

Background: The immune status is usually hampered in patients of diabetes mellitus. The global pandemic of diabetes principally involves type 2 diabetes. In diabetic patients higher prevalence of hepatitis B virus infection is also noted that leads to more severe complications. This study was conducted to determine the immune responses to hepatitis B vaccine in type 2 diabetic patients.

Methods: In this study 33 diabetic patients were included as experimental group and 34 non diabetic healthy persons were included as control group. All the participants were vaccinated with hepatitis B vaccine following 0, 1, 6 months schedule. The vaccine responses in diabetic and non diabetic group were compared depending on seromarkers (anti-HBs titer, IL-2 and IFN-?) following vaccination.

Results: The mean value of anti-HBs titer was lower in diabetic group (357.81 mIU/ml) than non diabetic group (621.24 mIU/ml) but the difference was not significant (p>0.05), the mean value of IFN-? was lower in diabetic group (0.1480 IU/ml) than non diabetic group (0.2788 IU/ml) and here the difference was significant (p<0.05), the mean value of serum IL-2 level was also lower in diabetic group (0.2611IU/ml) than non diabetic group (0.3691 IU/ml) but the difference was not significant (p>0.05).

Conclusion: The study revealed no statistically significant variation in anti-HBs and IL-2 but a diminished IFN-? level as the immune response in diabetic patients after HBV infection.

J MEDICINE January 2016; 17 (1) : 8-11

Downloads

Download data is not yet available.
Abstract
44
PDF
33

Author Biography

Ashesh Kumar Chowdhury, Department of Immunology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorder (BIRDEM), 122- Kazi Nazrul Islam Avenue, Shahbag, Dhaka-1000



Downloads

Published

2016-10-23

How to Cite

Chowdhury, A. K., Bokshi, S. K., Rahman, Z. F., Taher, M. A., & Choudhury, S. (2016). IL-2, IFN-?³ and anti-HBs based Immune Responses to Hepatitis B Vaccine in Type 2 Diabetic Patients. Journal of Medicine, 17(1), 8–11. https://doi.org/10.3329/jom.v17i1.30051

Issue

Vol. 17 No. 1 (2016)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).