Microorganisms Profile and their Antimicrobial Resistance Pattern Isolated from the Lower Respiratory Tract of Mechanically Ventilated Patients in the Intensive Care Unit of A Tertiary Care Hospital in Dhaka

Authors

  • Sarker Mohammad Tauhid Jamil Senior Medical officer, BIRDEM General Hospital, Dhaka
  • Mohammad Omar Faruq Professor, Critical Care Medicine, BIRDEM General Hospital, Dhaka
  • Shafiqus Saleheen Medical Officer, OSD, DGHS, Dhaka
  • Prodip Kumar Biswas Assistant Professor, Medicine, Dhaka Medical College, Dhaka
  • Mohammed Shahadat Hossain Assistant Professor, Medicine, OSD, DGHS. Attached to Faridpur Medical College, Faridpur
  • Syed Zakir Hossain Assistant Professor, Medicine, Dhaka Medical College, Dhaka
  • Mohammad Arifuzzaman Assistant Professor, Neurology, Dhaka Medical College, Dhaka
  • Bimal Kumar Basu Senior Consultant , Pathology, Pabna General Hospital, Pabna
  • Anwarul Kabir Professor, Gastroenterology, BSMMU, Dhaka
  • Ferdous Alam Assistant Professor, Surgery, BSMMU, Dhaka
  • Suresh Kumar Tulsan Assistant Professor, Department of Surgery, Kushtia Medical College, Kushtia

DOI:

https://doi.org/10.3329/jom.v17i2.30071

Keywords:

Antimicrobial resistance, microorganism profile, intensive care unit, mechanically ventilated patients

Abstract

Objective: Aim of the study was to know the microorganisms profile and determine the antibiotic resistance pattern of the LRT isolates from mechanically ventilated (MV) patients admitted to the ICU. This prospective observational study was done in Department of Critical Care Medicine (ICU) of BIRDEM General Hospital Dhaka from July, 2011 to December, 2011.

Methods: Blind Tracheal Aspirate or Broncho Alveolar Lavage or both from 110 consecutive patients (total 130 samples) admitted to the ICU requiring MV were cultured, identified, and antibiotic sensitivity was performed by standard methods.

Results: A total of 130 samples were analyzed. Growth was obtained in 93.8% of the samples yielding 143 organisms. Many (21 samples) yielded more than one organism. The major organism isolated were Acinetobacter sp. (54.5%), Pseudomonas sp.(14.7%), Klebsiella sp. (7.7%).Candida sp. (7.0%), Staphylococcus aureus(7.0%), Escherichia coli (4.9%).Proteus and Flavobacterium accounted for 4.2% of the isolates. All the isolates were highly resistant (>90%) to cephalosporins and >70% to fluoroquinolones. The frequency of third generation cephalosporin resistant E. coli, Klebsiellaand imipenem resistant Pseudomonas and Acinetobacter were>90%. Acinetobacter was remarkably resistant to most antibiotics including imipenem (>90% resistant) and Piperacillin+Tazobactum (>85% resistant), but most of the members of the Enterobacteriacae group and Acinetobacter showed maximum sensitivity to colistin (80%-100%).

Conclusion: Nonfermenters Gram Negative Bacilli (GNB)-Acinetobacter sp. & Pseudomonas sp. are the most common etiological agents of LRT infections in ICU. There is an alarmingly high rate of resistance to cephalosporin and ²â-lactamase inhibitor group of drugs. Colistin was found to be the most sensitive drug against all GNB.

J MEDICINE July 2016; 17 (2) : 91-94

Downloads

Download data is not yet available.
Abstract
39
PDF
36

Author Biography

Sarker Mohammad Tauhid Jamil, Senior Medical officer, BIRDEM General Hospital, Dhaka



Downloads

Published

2016-10-23

How to Cite

Jamil, S. M. T., Faruq, M. O., Saleheen, S., Biswas, P. K., Hossain, M. S., Hossain, S. Z., Arifuzzaman, M., Basu, B. K., Kabir, A., Alam, F., & Tulsan, S. K. (2016). Microorganisms Profile and their Antimicrobial Resistance Pattern Isolated from the Lower Respiratory Tract of Mechanically Ventilated Patients in the Intensive Care Unit of A Tertiary Care Hospital in Dhaka. Journal of Medicine, 17(2), 91–94. https://doi.org/10.3329/jom.v17i2.30071

Issue

Vol. 17 No. 2 (2016)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).