Frequency of Extended-Spectrum Beta-Lactamase Producing Organisms Causing Urinary Tract Infection and Their Antibiotic Sensitivity Pattern

Authors

  • Md Raziur Rahman Associate Professor, Department of Internal Medicine, BIRDEM General Hospital, Dhaka
  • Muhammad Abdur Rahim Assistant Professor, Department of Nephrology, BIRDEM General Hospital, Dhaka
  • Samira Rahat Afroze Registrar, Department of Internal Medicine, BIRDEM General Hospital, Dhaka
  • Chinmay Shaha Poddar Assistant Registrar, Department of Internal Medicine, BIRDEM General Hospital, Dhaka
  • Khwaja Nazim Uddin Professor, Department of Internal Medicine, BIRDEM General Hospital, Dhaka

DOI:

https://doi.org/10.3329/jom.v18i1.31162

Keywords:

antibiotic, extended-spectrum beta-lactamase, sensitivity, urinary tract infection

Abstract

Background: The spectrum of bacteria causing urinary tract infection (UTI) and their antibiotic sensitivity pattern is not uniform. Escherichia coli and Klebsiella sp. are two common organisms responsible for UTI through-out the world. The incidence of UTI due to infection with extended-spectrum beta-lactamase (ESBL) producing organisms are increasing. This study was aimed to describe the frequency of ESBL positive organisms causing UTI and their antibiotic sensitivity pattern.

Methods: This cross-sectional study was done in the Department of Internal Medicine, BIRDEM General Hospital from January to April, 2016.

Results: Total number of patients was 137 with females predominance (M:F ratio 1 : 3.7). Mean age was 60.3 ±11.7 years. Most patients (131, 95.6%) of the study population were diabetic and glycaemic control was poor (mean HbA1c 9.3 ±2.3) in these subjects. Common symptoms were fever, vomiting, increased urinary frequency, dysuria, suprapubic pain, and loin pain. Neutrophilic leukocytosis was common (94.9%). E. coli (73.7%) was the commonest aetiological agent followed by Klebsiella (8.8%), Enterococcus (4.4%), Citrobacter (3.6%), Staphylococcus aureus (3.6%), Acinetobacter (2.9%), Enterobacter (1.5%), and Pseudomonas (1.5%). Over half of E. coli and of Klebsiella sp. and 100% of Enterobacter organisms were ESBL positive. Imipenem (100%), amikacin, netilmycin,and nitrofurantoin were among the most sensitive antibiotics.

Conclusion: More than half (71, 51.82%) of UTI cases were due to ESBL positive organisms. Imipenem, amikacin, netilmycin, and nitrofurantoin remain the drug of choice.

J MEDICINE January 2017; 18 (1) : 3-5

Downloads

Download data is not yet available.
Abstract
35
PDF
39

Author Biography

Md Raziur Rahman, Associate Professor, Department of Internal Medicine, BIRDEM General Hospital, Dhaka



Downloads

Published

2017-01-17

How to Cite

Rahman, M. R., Rahim, M. A., Afroze, S. R., Poddar, C. S., & Uddin, K. N. (2017). Frequency of Extended-Spectrum Beta-Lactamase Producing Organisms Causing Urinary Tract Infection and Their Antibiotic Sensitivity Pattern. Journal of Medicine, 18(1), 3–5. https://doi.org/10.3329/jom.v18i1.31162

Issue

Vol. 18 No. 1 (2017)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).