Evaluation of Efficacy and Safety of Oral Olmesartan+ Chlorthalidone Combination in the Management of Hypertension in Indian Patients

Authors

  • Ashok Khanna Consulting Physician, Jabalpur
  • AA Faruqui Clinical Pharmacologist

DOI:

https://doi.org/10.3329/jom.v18i1.31163

Keywords:

Diastolic, Systolic, Blood Pressure, Hypertension, Fixed dose combination

Abstract

Hypertension is the most prevalent chronic disease in India and its prevalence is rapidly increasing among urban and rural populations. Reducing blood pressure can decrease cardiovascular risk and all cause mortality. This study was conducted to assess the efficacy and safety of fixed dose combination of Olmesartan 40 mg and Chlorthalidone12.5mg. 30 hypertensive patients having systolic blood pressure ? 160 mmHg and diastolic blood pressure ?100 mmHg who were uncontrolled on monotherapy with olmesartan were enrolled in this study. The treatment period was of 60 days and patients were administered once daily fixed dose combination of Olmesartan40 mg and Chlorthalidone 12.5 mg. Patients were evaluated on 15th, 30th and 60th days of treatment.There was statistically significant (p<0.0001) decrease in systolic blood pressure from baseline to 15th, 30th and 60thday of treatmentmean±SD (179.1±13.38 mmHg vs. 169.3±13.05, 154.3±13.31, and 142.7±6.91mmHg) respectively. Similarly the diastolic blood pressure (DBP) was significantly (p<0.0001) reduced from the baseline to the 15th, 30th and 60thday of treatment (94.97±5.75mmHg vs.86.67±4.79, 80.33±1.82 and 76.7±4.32 mmHg respectively). Thus fixed dose combination of Olmesartan and Chlorthalidonewas found to be effective and safe option for the optimal management of hypertension.

J MEDICINE January 2017; 18 (1) : 6-9

Downloads

Download data is not yet available.
Abstract
31
PDF
44

Author Biography

Ashok Khanna, Consulting Physician, Jabalpur



Downloads

Published

2017-01-17

How to Cite

Khanna, A., & Faruqui, A. (2017). Evaluation of Efficacy and Safety of Oral Olmesartan+ Chlorthalidone Combination in the Management of Hypertension in Indian Patients. Journal of Medicine, 18(1), 6–9. https://doi.org/10.3329/jom.v18i1.31163

Issue

Vol. 18 No. 1 (2017)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).