Cutaneous Amyloidosis: A Pilot Study at a Teaching Hospital in New Delhi

Authors

  • Zeeba S Jairajpuri Department of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi
  • Safia Rana Department of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi
  • Shaan Khetrapal Department of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi
  • Pooja Arora Department of Dermatology, Post Graduate Institute of Medical Education & Research & Dr Ram Manohar Lohia hospital Delhi
  • Sujata Jetley Department of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi

DOI:

https://doi.org/10.3329/jom.v19i1.34838

Keywords:

Cutaneous, amyloidosis, macular, lichen

Abstract

Background: Amyloidosis is characterized by the deposition of polymeric fibrillar proteins in the extracellular compartment in tissues and organs ultimately leading to damage with functional compromise. Cutaneous amyloidosis is clinically classified into more common macular, papular, and the rarer nodular form. The present study was undertaken with the aim to histopathologically analyze and characterize clinically diagnosed amyloid cases.

Methods:The present study was a retrospective analysis of skin biopsies conducted over a one year period. Data on the age and presenting clinical features were retrieved from the accompanying laboratory request forms or patients records wherever available. All skin biopsies with a histologic diagnosis of amyloid were retrieved and reviewed, the pattern of amyloid deposition identified and classified. Special stains including Congo Red stain was done in all the cases.

Results: Histopathological confirmation of cutaneous amyloidosis was seen in nine out of fourteen cases and was confirmed by positive Congo-red stain under polarized light. Out of this seven were females and two were males. Majority of the lesions were of macular type. In all the nine cases, family history was negative and no evidence of systemic involvement was noted, either clinically or based upon the lab investigations.

Conclusions: In this pilot study of 9 cases, histologically diagnosed as cutaneous amyloidosis we noted a female preponderance in young and middle-aged persons. Macular amyloidosis was the most common form and the most common site of involvement, the upper extremity and the inter-scapular/back region.

J MEDICINE Jan 2018; 19 (1) : 35-39

Downloads

Download data is not yet available.
Abstract
24
PDF
28

Downloads

Published

2017-12-07

How to Cite

Jairajpuri, Z. S., Rana, S., Khetrapal, S., Arora, P., & Jetley, S. (2017). Cutaneous Amyloidosis: A Pilot Study at a Teaching Hospital in New Delhi. Journal of Medicine, 19(1), 35–39. https://doi.org/10.3329/jom.v19i1.34838

Issue

Vol. 19 No. 1 (2018)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).