Need of Combining Proton Pump Inhibitors with Prokinetics: A Prospective Observational Survey Conducted in India

Authors

  • Arif Ahmed Faruqui Clinical Pharmacologist, Associate Professor, Department of Pharmacology, SNIMS

DOI:

https://doi.org/10.3329/jom.v19i2.37223

Keywords:

Delayed gastric emptying, Dysmotility score, FSSG score, Gastroparesis, GERD, Reflux score

Abstract

Background: Gastro esophageal reflux disease (GERD), a highly prevalent disorder has adverse impact on quality of life. An estimated 40% of GERD patients have incomplete response to standard PPI therapy. For these PPI refractory patients, doubling the PPI dose or switching to another PPI are pursued by the treating physicians that might not be optimal. Therefore, an appropriate second line treatment should focus on addition of gastro-prokinetic drugs that stimulates gastric motility.

Materials & Methods: This was a prospective observational study conducted in 118 patients suffering from symptoms suggestive of GERD, at four centers in Indian National Capital region to assess the overlap between GERD and delayed gastric emptying and to predict the need for combination therapy of PPI with pro-kinetic drug using Frequency Scale for the Symptoms of GERD (FSSG) score.

Results: The mean total FSSG score was 16.37 ± 7.50. From 118 patients, 98 (83.05%) met the criteria for GERD with FSSG total score more than eight. The mean reflux score was 7.43 ± 4.08, while the mean dysmotility score was 8.94 ± 4.83. GERD patients in this study have a high mean FSSG score, whereas dysmotility symptoms proved to be more dominant than acid reflux.

Conclusion: Based on the findings of this study, combination therapy of PPI with prokinetics is recommended in subsets of patients with high FSSG score

J MEDICINE JUL 2018; 19 (2) : 74-78

Downloads

Download data is not yet available.
Abstract
61
PDF
36

Author Biography

Arif Ahmed Faruqui, Clinical Pharmacologist, Associate Professor, Department of Pharmacology, SNIMS



Downloads

Published

2018-07-10

How to Cite

Faruqui, A. A. (2018). Need of Combining Proton Pump Inhibitors with Prokinetics: A Prospective Observational Survey Conducted in India. Journal of Medicine, 19(2), 74–78. https://doi.org/10.3329/jom.v19i2.37223

Issue

Vol. 19 No. 2 (2018)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).