Haemophagocytic Lymphohistiocytosis Associated with Dengue Fever - A case series

Authors

  • Quazi Tarikul Islam Professor of Medicine, Popular Medical College, Dhaka, Bangladesh
  • Hirinmoy Barman Sagor Assistant Registrar of Medicine, Popular Medical College Hospital, Dhaka, Bangladesh
  • Tasmina Chowdhury Tuli Registrar of Medicine, Popular Medical College Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jom.v21i2.50220

Keywords:

Haemophagocytic Lymphohistiocytosis, Dengue, Methylprednisolone, MODS

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening medical condition characterized by hyperphagocytosis secondary to an inappropriate over-activation of macrophages and lymphocytes that driven by excessive cytokines production which resulted in cellular destructions. Dengue induced hemophagocytic lymphohistiocytosis (HLH) is a serious condition and may prove fatal if not detected early and treated appropriately. Diagnosis of HLH is challenging and usually missed as clinical and laboratory findings are nonspecific. It should be suspected with prolonged fever beyond seven days associated with splenomegaly, hyperferritinemia, worsening cytopenias and development of multiorgan dysfunction. A proportion of patients recovered with supportive therapy, however most required interventions with corticosteroids, intravenous immunoglobulin or chemotherapy. We report 3 cases of dengue associated HLH . Among them 2 patients were treated with steroid with good outcome, and one died from MODS.

J MEDICINE JUL 2020; 21 (2) : 123-126

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Published

2020-11-09

How to Cite

Islam, Q. T., Sagor, H. B., & Tuli, T. C. (2020). Haemophagocytic Lymphohistiocytosis Associated with Dengue Fever - A case series. Journal of Medicine, 21(2), 123–126. https://doi.org/10.3329/jom.v21i2.50220

Issue

Vol. 21 No. 2 (2020)

Section

Case Reports

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