Cytomegalovirus Antibodies Amongst Immunocompromised (HIV) Patients At Lagos University Teaching Hospital (LUTH) Idi - Araba, Lagos

Authors

  • AA Akinbami Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine
  • AS Akanmu Department of Haematology and Blood Transfusion, Lagos University Teaching Hospital Idiaraba.
  • TA Adeyemo Department of Haematology and Blood Transfusion, Lagos University Teaching Hospital Idiaraba.
  • KO Wright Department of Community Health and Primary Health Care, Lagos State University College of Medicine.
  • MO Dada Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine
  • AO Dosunmu Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine

DOI:

https://doi.org/10.3329/jom.v11i2.5462

Keywords:

Seroprevalence, CMV IgG/IgM, ELISA, healthy blood donors, HIV-infected patients

Abstract

Background: CMV infection constitutes a real risk of pathogenecity in immunocompromised patient. HIV- infected
patients who require transfusion are at high risk of developing symptomatic CMV infection when they are transfused
with CMV-infected donor blood. This study intends to determine CMV infection risk in correlation with blood
transfusion in a population of HIV- infected patients
Methods: The study was carried out amongst clients attending HIV clinic at Lagos University Teaching Hospital
(LUTH), who were recruited consecutively. Replacement blood donors of the hospital were recruited as controls. A
total of 10mls of blood sample was collected per consenting participant. The serum obtained from 5ml of blood was
assayed for CMV IgG/IgM using an enzyme- linked immunosorbent assay (ELISA) based Kit whilst full blood count
and CD4 cell counts were also performed on the remaining 5mls.
Results: A total of 129 HIV-infected were studied. All (100%) were IgG anti-CMV positive. 8 (6.6%) were IgM anti-
CMV positive. This difference was found to be statistically significant P=0.004, (P<0.05). Of 122 replacement blood
donor controls, 118 (96%) of them were IgG anti-CMV positive whilst 26 (19.5%) of 121 were IgM anti-CMV
positive.The mean CD4+ cell count of HIV-infected patients was (234 ± 173.181). Previous history of blood
transfusion did not affect CMV antibody positivity directly.
Conclusion: The seroprevalence of CMV is very high in HIV-infected patients, which is comparable to the
seroprevalence amongst the general population The use of leukoreduced blood units for anaemic HIV infected
patients, is recommended.

Keywords: Seroprevalence; CMV IgG/IgM; ELISA; healthy blood donors; HIV-infected patients.

DOI: 10.3329/jom.v11i2.5462

J MEDICINE 2010; 11 : 151-154

Downloads

Download data is not yet available.
Abstract
1159
PDF
633

Downloads

How to Cite

Akinbami, A., Akanmu, A., Adeyemo, T., Wright, K., Dada, M., & Dosunmu, A. (2010). Cytomegalovirus Antibodies Amongst Immunocompromised (HIV) Patients At Lagos University Teaching Hospital (LUTH) Idi - Araba, Lagos. Journal of Medicine, 11(2), 151–154. https://doi.org/10.3329/jom.v11i2.5462

Issue

Vol. 11 No. 2 (2010)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).