Effect of N-Acetylcysteine on IL-10 and Total Lymphocyte Count in HIV Infected Patients Undergoing Antiretroviral Treatment

Authors

  • Filia Yuniza Magister of Biomedical Science, Faculty of Medicine, Sriwijaya University, Indonesia
  • Eddy Mart Salim Department of Internal Medicine, Muhammad Hoesin Central Hospital, Palembang
  • Zen Hafy Department of Biomedical Science, Faculty of Medicine, Sriwijaya University, Indonesia
  • Nova Kurniati Department of Internal Medicine, Muhammad Hoesin Central Hospital, Palembang
  • Harun Hudari Department of Internal Medicine, Muhammad Hoesin Central Hospital, Palembang
  • Erial Bahar Department of Biomedical Science, Faculty of Medicine, Sriwijaya University, Indonesia

DOI:

https://doi.org/10.3329/jom.v22i2.56700

Keywords:

HIV/AIDS, interleukin 10, NAC, total lymphocyte count

Abstract

Objective: To determine NAC oral administration’s effect on changes in IL-10 levels and total lymphocyte count (TLC) in patients with HIV/AIDS in Dr Mohammad Hoesin Hospital, Palembang.

Material and Methods: This study was a double-blind, randomized clinical trial. A total of 32 HIV/AIDS patients undergoing ARV treatment were randomly divided into two groups: the placebo and NAC groups. In the placebo group, patients were given capsules containing lactose at a dose of 3x1 capsules/ day, while the NAC group, were given NAC at a dose of 3x200 mg/day. Each group was treated for 12 weeks.

Results: NAC administration significantly reduced IL-10 levels P= 0.038 but could not significantly increase TLC after treatment P= 0.376. However, TLC on the NAC group remained higher when compared with TLC on the placebo group.

Conclusion: NAC administration significantly reduced levels of IL-10 and increased TLC; therefore, NAC has potential effects of increasing the effectiveness of antiretroviral therapy in HIV/AIDS patients, although it still needs to be studied further.

J MEDICINE 2021; 22: 114-118

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Published

2021-12-01

How to Cite

Yuniza, F. ., Salim, E. M. ., Hafy, Z. ., Kurniati, N. ., Hudari, H. ., & Bahar, E. (2021). Effect of N-Acetylcysteine on IL-10 and Total Lymphocyte Count in HIV Infected Patients Undergoing Antiretroviral Treatment. Journal of Medicine, 22(2), 114–118. https://doi.org/10.3329/jom.v22i2.56700

Issue

Vol. 22 No. 2 (2021)

Section

Original Articles

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