The Potential Role of Soluble Angiotensin Converting Enzyme 2 As A Left Ventricular Dysfunction Biomarker

Authors

  • Sidhi Laksono Head of Cardiac Catheterization Laboratory, Department of Cardiology and Vascular Medicine, RSUD Pasar Rebo, East Jakarta, Indonesia
  • Budhi Setianto Department of Cardiology and Vascular Medicine of National Cardiovascular Center of Harapan Kita, Faculty of medicine of Universitas Indonesia, Jakarta, Indonesia
  • Ananta Siddhi Prawara Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

DOI:

https://doi.org/10.3329/jom.v22i2.56702

Keywords:

ACE2, biological marker, left ventricular dysfunction, prognostic, renin-angiotensin-aldosterone system

Abstract

Left ventricular (LV) dysfunction is a part of the common pathophysiologic mechanism for the development of heart failure (HF). LV dysfunction can be classified into left ventricular systolic dysfunction (LVSD) and left ventricular diastolic dysfunction (LVDD). Currently, B-type Natriuretic Peptide (BNP) and N-Terminal Pro-BNP (NT-proBNP) are the most common marker used to determine HF. Both of them are used as diagnostic and prognostic marker. Angiotensin Converting Enzyme 2 (ACE2) was found as an ACE homolog, located in the cell membrane of the heart. ACE2 has a cardioprotective role in turning AngII to Ang1-7. ACE2 can be cleaved by A Disintegrin and Metalloproteinase 17 (ADAM17)/TNF-a converting enzyme (TACE) so that it can be detected in the plasma as soluble ACE2. Soluble ACE2 possessed a potential role as LV dysfunction diagnostic or prognostic biomarker.

J MEDICINE 2021; 22: 127-131

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Published

2021-12-01

How to Cite

Laksono, S. ., Setianto, B. ., & Prawara, A. S. . (2021). The Potential Role of Soluble Angiotensin Converting Enzyme 2 As A Left Ventricular Dysfunction Biomarker. Journal of Medicine, 22(2), 127–131. https://doi.org/10.3329/jom.v22i2.56702

Issue

Vol. 22 No. 2 (2021)

Section

Original Articles

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