Clinical Consequences and Economic Burden Associated with Febrile Neutropenia in Hospitalized Cancer Patients: A Prospective Study

Authors

  • Tamanna Bahar Department of Haematology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
  • Shaila Rahman Department of Medicine, Enam Medical College & Hospital, Dhaka, Bangladesh
  • Zulfia Zinat Chowdhury Department of Haematology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
  • Tania Kabir Bangladesh Secretariat Clinic, Dhaka, Bangladesh
  • Fahmida Akther Deapartment of Medicine,Jalalabad Ragib Rabeya Medical College and Hospital, Sylhet, Bangladesh
  • Salina Haque Department of Haematology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
  • AKM Mynul Islam Department of Haematology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
  • Mohammad Ali Department of Haematology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
  • Md Mahbubur Rahman Department of Haematology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jom.v23i1.57937

Keywords:

Febrile neutropenia, economic burden, consequence, oncological emergency

Abstract

Objective: Febrile neutropenia (FN) is viewed as the most decimating oncological crisis particularly inchemotherapy-incited patients. The primary objective of the study was to identify the total directexpenditure of patients during febrile neutropenia with clinical consequences and the secondary aim wasto find out the factors associated with higher cost.

Materials and Method: This was a single-centered hospital-based study in the largest and only specializedcancer care centre in Bangladesh in the government sector. This prospective study was done in theinpatients’ department of the National Institute of Cancer Research and Hospital from April 2020 toJanuary 2021. The primary outcome was the out-of-pocket patient payments (adjusted by governmentsubsidy) per FN episode. Univariate analysis and multiple linear regression were conducted to identifythe factors associated with higher costs.

Results and Discussions: A total of 101 patients were enrolled in the study. The mean (SD) age was33.49 (±15.79) years. Of the 101 participants, 63.4% were male. Among the patients, 13.9% died during theepisode and 86.1% recovered. Having co-morbidities and COVID-19 were associated with an increasedrisk of death. The mean cost was US$ 999.44 (±499.05) and the mean length of hospital stay was 21.98(±9.3) days. The longer hospital stay was significantly associated with higher costs.

Conclusion: This study will help to ascertain the hospital cost and clinical outcome of FN whichultimately can help in policymaking strategy.

J MEDICINE 2022; 23: 48-53

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Published

2022-02-03

How to Cite

Bahar, T. ., Rahman, S. ., Chowdhury, Z. Z. ., Kabir, T. ., Akther, F. ., Haque, S. ., Islam, A. M. ., Ali, M. ., & Rahman, M. M. . (2022). Clinical Consequences and Economic Burden Associated with Febrile Neutropenia in Hospitalized Cancer Patients: A Prospective Study. Journal of Medicine, 23(1), 48–53. https://doi.org/10.3329/jom.v23i1.57937

Issue

Vol. 23 No. 1 (2022)

Section

Original Articles

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