Association of Interleukin-4 in Immunoglobulin-E Mediated Asthma: A Cross Sectional Study

Authors

  • Raghdah Maytham Hameed Departments of Medical Microbiology, University of Babylon, Babylon, Iraq
  • Haidar Abdul Amir Najim Abood Departments of Pharmacology, University of Kerbala, Kerbala, Iraq
  • Huda H Al-Hasnawy Departments of Medical Microbiology, University of Babylon, Babylon, Iraq

DOI:

https://doi.org/10.3329/jom.v24i2.67270

Keywords:

Asthma, IgE, IL-4, Severity

Abstract

Backgrounds: Interleukin 4 (IL 4) is a cytokine associated with the cause of several allergic diseases such as asthma due to their function in the differentiation of T helper type 2 lymphocytes and induction of the IgE isotype switch.

Object: The study aims to determine the association IL-4 level with total serum IgE levels and asthma severity. Methods: A cross-section study was performed. Eighty-seven subjects were recruited from Karbala Teaching Hospital for Children in the period extending from January 25 to May 24, 2022, including children with asthma, were subjected to measure IL 4 level using Elabscience ELISA kit and measured total IgE level using AccuBind IgE ELISA kit.

Results: Eighty-seven subjects of asthmatic children in which the mean age was 7.833 ± 3.652. There are 65.52% and 34.48% of asthmatic children (male and female, respectively). Total serum IgE was 398.889 ± 227.156 IU/ml, while the IL-4 level was 5.18 ± 8.224. There was a significant difference in IL 4 levels depending on asthma severity (P= 0.037). IL-4 levels in severe persistent asthma were higher than IL-4 levels in mild and moderate persistent asthma. Further, there was a highly significant difference in IL 4 levels depending on asthma controlled (P= 0.004). IL-4 levels in not well-controlled asthma were higher than IL-4 levels in well and partial controlled asthma. In addition, there was no significant correlation between IL-4 levels and total serum IgE levels (P=0.436).

Conclusion: IL 4 has an important role in predicting asthma severity and asthma control in children. These findings have important implications for the treatment of IgE-mediated asthma. Despite this, IL 4 levels have no significant correlation with total serum IgE levels.

J MEDICINE 2023; 24(2): 89-95

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Published

2023-07-02

How to Cite

Hameed, R. M. ., Najim Abood, H. A. A., & Al-Hasnawy, H. H. (2023). Association of Interleukin-4 in Immunoglobulin-E Mediated Asthma: A Cross Sectional Study. Journal of Medicine, 24(2), 89–95. https://doi.org/10.3329/jom.v24i2.67270

Issue

Vol. 24 No. 2 (2023)

Section

Original Articles

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