Adverse Drug Reactions: Trimethoprim-sulfamethoxazole Induced Myoclonus

Authors

  • Noah Vermette Saint Louis University School of Medicine, St. Louis, MO, USA
  • Farzana Hoque Associate Professor of Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA

DOI:

https://doi.org/10.3329/jom.v26i1.79066

Keywords:

adverse drug reactions, myoclonus, tremor, TMP-SMX, BactrimⓇ, trimethoprim-sulfamethoxazole

Abstract

A 58-year-old male presented with complaints of new-onset periodic tremors and spasms for a few days. The patient was found to have recently started a course of trimethoprim-sulfamethoxazole (TMP-SMX) due to concern for a suspected urinary tract infection found incidentally after presenting for wound dehiscence following L1-L4 laminectomies a month prior. A neurological workup revealed was unremarkable, resulting in the exploration of further potential causes. A literature review revealed a case report that reported myoclonus as an adverse effect of TMP-SMX. So, the medication was discontinued, resulting in a resolution of myoclonus. The purpose of this case report is to make clinicians aware of a rare reversible adverse drug reaction from the use of TMP-SMX.

J MEDICINE 2025; 26: 77-79

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Published

2025-02-23

How to Cite

Vermette , N., & Hoque, F. (2025). Adverse Drug Reactions: Trimethoprim-sulfamethoxazole Induced Myoclonus . Journal of Medicine, 26(1), 77–79. https://doi.org/10.3329/jom.v26i1.79066

Issue

Vol. 26 No. 1 (2025)

Section

Case Reports

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