Detection of Mycobacterium Tuberculosis in Extrapulmonary Specimens and Drug Sensitivity Pattern in a Tertiary Level Chest Disease Hospital of Bangladesh

Authors

  • Md Ziaul Karim Assistant Professor, Department of Respiratory Medicine, National Institute of Diseases of Chest & Hospital (NIDCH), Mohakhali
  • Mohammad Ashik Imran Khan Medical Officer, Upazilla Health Office, Sadar, Munshiganj
  • Farzana Banu Assistant Professor, Department of Obstetrics & Gynecology, Sir Salimullah Medical College & Mitford Hospital
  • Md Zahirul Islam Shakil Assistant Professor, Department of Respiratory Medicine, National Institute of Disease of Chest & Hospital, Mohakhali
  • Golam Sarwar Liaquat Hossain Bhuiyan Assistant Professor, Department of Respiratory Medicine, National Institute of Disease of Chest & Hospital, Mohakhali
  • Md Zakaria Al Aziz Associate Professor, Department of Medicine, Dhaka Medical College Hospital, Dhaka

DOI:

https://doi.org/10.3329/jom.v26i2.84353

Keywords:

: Extrapulmonary Tuberculosis, drug sensitivity pattern, Bangladesh

Abstract

Background: Extra-pulmonary tuberculosis (EPTB) is a growing public health concern, and data on drug resistance in EPTB are limited.

Objective: To detect Mycobacterium Tuberculosis in extrapulmonary specimens and to find out identity the pattern of drug sensitivity among extrapulmonary specimens

Methods: This cross-sectional study was conducted at the NTRL (National Tuberculosis Reference Laboratory) of the National Institute of Diseases of Chest and Hospital (NIDCH), Bangladesh, from January 2024 to December 2024. This study included 100 patients suspected of suffering from extrapulmonary Mycobacterium Tuberculosis infection. Clinical specimens were obtained from these extrapulmonary sites and were subjected to the GeneXpert test to detect the presence of Mycobacterium TB. Drug sensitivity patterns were tested in the samples that yielded positive results.

Results:The Mean age of the patients was 39.25 ± 17.99 years. Most of the patients were 21 – 40 years old.The majority of the patients were male (64.0%).The male-to-female ratio was 1.78:1.The most common extrapulmonary sample tested was pleural fluid. Mycobacterium Tuberculosis was detected in 28.0% of the samples. Extrapulmonary Mycobacterium tuberculosis was predominant among the younger patients. The mean age of patients with EPTB was significantly lower than that of patients without EPTB (29.53 ± 16.27 vs 43.08 ± 17.27; p £0.001). Sensitivity to first and second-line anti-tubercular drugs was evaluated in the extrapulmonary specimens that tested positive. Both first-line anti-tubercular drugs (Isoniazid) and second-line anti-tubercular drugs (Aminoglycosides, Kanamycin, fluoroquinolones, and Ethionamide) were found to be sensitive in 85.7% of cases and resistant in 14.3% of cases respectively.

Conclusion: EPTB remains a significant health problem, particularly affecting male and young men with a substantial proportion demonstrating drug resistance.

J MEDICINE 2025; 26(2): 89-93

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Published

2025-09-28

How to Cite

Karim, M. Z., Khan, M. A. I., Banu, F., Shakil, M. Z. I., Hossain Bhuiyan, G. S. L., & Aziz, M. Z. A. (2025). Detection of Mycobacterium Tuberculosis in Extrapulmonary Specimens and Drug Sensitivity Pattern in a Tertiary Level Chest Disease Hospital of Bangladesh. Journal of Medicine, 26(2), 89–93. https://doi.org/10.3329/jom.v26i2.84353

Issue

Vol. 26 No. 2 (2025)

Section

Original Articles

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