Diversity of Uropathogens and Ciprofloxacin Resistance Patterns Among Females of Different Age Groups in a Tertiary Care Hospital in Bangladesh

Authors

  • Samira Afroz Associate Professor, Department of Microbiology, Ad-din Women’s Medical College, 02, Boro Moghbazar, Dhaka 1217
  • Md Nahiduzzamane Shazzad Associate Professor, Department of Rheumatology, Bangladesh Medical University, Dhaka https://orcid.org/0000-0002-8535-4259
  • Asma Rahman Assistant Professor, Department of Microbiology, Ad-din Women’s Medical College, 02, Boro Moghbazar, Dhaka-1217
  • Afzalunnessa Binte Lutfor Professor and Head, Department of Microbiology, Ad-din Women’s Medical College, 02, Boro Moghbazar, Dhaka-1217
  • Mahbubur Rahman Assistant Professor, Department of Internal Medicine, Bangladesh Medical University, Dhaka

DOI:

https://doi.org/10.3329/jom.v26i2.84358

Keywords:

Urinary Tract Infection, Ciprofloxacin, Bangladesh

Abstract

Introduction: Urinary tract infections (UTIs) are the most common bacterial infections globally, with a particularly high burden among females. Ciprofloxacin has long been a key antimicrobial for empirical UTI treatment, but increasing resistance raises concern, especially in regions with limited surveillance data.This study aimed to investigate the diversity of uropathogens and ciprofloxacin resistance patterns across different age groups of female patients in a tertiary care hospital in Bangladesh.

Methods: A retrospective cross-sectional study was conducted from January to December 2022 at the Department of Microbiology,Ad-din Women’s Medical College Hospital, Dhaka. Midstream urine samples from the suspected female patients of UTI were cultured and analyzed using standard microbiological techniques. Antimicrobial resistance to ciprofloxacin was evaluated using the Kirby-Bauer disk diffusion technique, and the results were interpreted per the 2020 guidelines of the Clinical and Laboratory Standards Institute.

Results: Out of 1930 samples, 323 (16.74%) were ciprofloxacin-sensitive, while 1607 (83.26%) were resistant. Most infections occurred in the 15–49 age group (67.88%). Escherichia coli was the most prevalent uropathogen (43.32%), followed by other staphylococci species, specifically coagulase-negative Staphylococci (OSS) (24.61%), and Enterobacter spp. (12.54%), and Klebsiella spp. (6.58%). Ciprofloxacin resistance was highest among Enterococci (96.97%), followed by Klebsiella spp. (88.19%) and E. coli (85.17%). Resistance was significantly higher in younger age groups (p < 0.0001).

Conclusion:This study reveals alarmingly high ciprofloxacin resistance rates among uropathogens, particularly in reproductive-age females. The findings underscore the urgent need for local antibiotic stewardship, culture-guided therapy, and age-specific empirical treatment guidelines to combat rising antimicrobial resistance in Bangladesh.

J MEDICINE 2025; 26(2): 117-123

Downloads

Download data is not yet available.
Abstract
24
PDF
15

Downloads

Published

2025-09-28

How to Cite

Afroz, S., Shazzad, M. N., Rahman, A., Lutfor, A. B., & Rahman, M. (2025). Diversity of Uropathogens and Ciprofloxacin Resistance Patterns Among Females of Different Age Groups in a Tertiary Care Hospital in Bangladesh. Journal of Medicine, 26(2), 117–123. https://doi.org/10.3329/jom.v26i2.84358

Issue

Vol. 26 No. 2 (2025)

Section

Original Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).