Base Catalyzed Intra Molecular Wittig Reaction Between [2-Ethoxy-3-(4-Substituted Phenyl)-2-Propenylidene] Triphenyl Phosphonium Bromides With Bifunctional Carbonyl Compounds

Abstract

5-ethoxycarbonyl-2-(alkyloraryl)-4-(alkyloraryl)-2-cylopenten-1-one and 2-ethoxycar-bonyl-5-(alkyl or aryl)-3-(alkyl or aryl)-2- cyclopenten-1-one derivatives and ethyl-6-(alkyl or aryl)-3-(alkyl or aryl)-6-oxo-2,4-hexadienoate derivatives have been prepared by a single step reaction between [2-ethoxy-3-(4-subsituted phenyl)-2-propenylidene triphenyl phosphonium bromides and bifunctional carbonyl compounds e.g glyoxal in presence of a base. The mechanism of the formation of the products is also proposed. Key words: Wittig Reaction, Triphenyl phosphonium bromide, Hexadienoate, Cyclopentanoate Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website