Formulation and Evaluation of Transdermal Films of Salbutamol Sulphate

Abstract

Transdermal drug delivery systems of salbutamol sulphate using eudragit RL100 and PVP were developed by solvent casting technique employing mercury as a substrate. Propylene glycol was used as a plasticizer. The prepared films exhibited satisfactory physico-chemical characteristics. In vitro permeation profiles across the guinea-pig dorsal skin using K-C diffusion cell are reported. Incorporating PEG-400 and tween 60 into the films enhanced the permeation across guinea-pig skin; permeation rate was greater with films containing PEG-400. The permeation followed zero order kinetics and mechanism was found to be matrix diffusion. Key words: Salbutamol sulphate, Guinea pig skin, Permeation enhancer. Dhaka Univ. J. Pharm. Sci. Vol.4(2) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website